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Genes 2015, 6(2), 299-324; doi:10.3390/genes6020299

Chromatin Remodelers: From Function to Dysfunction

Biochemistry Center Regensburg, Laboratory of Chromatin Dynamics and Nuclear Architecture, University of Regensbrug, Universitätstraße 31, Regensburg DE-93053, Germany
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Academic Editor: Jessica Tyler
Received: 30 April 2015 / Revised: 1 June 2015 / Accepted: 3 June 2015 / Published: 12 June 2015
(This article belongs to the Special Issue Chromatin Dynamics)
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Abstract

Chromatin remodelers are key players in the regulation of chromatin accessibility and nucleosome positioning on the eukaryotic DNA, thereby essential for all DNA dependent biological processes. Thus, it is not surprising that upon of deregulation of those molecular machines healthy cells can turn into cancerous cells. Even though the remodeling enzymes are very abundant and a multitude of different enzymes and chromatin remodeling complexes exist in the cell, the particular remodeling complex with its specific nucleosome positioning features must be at the right place at the right time in order to ensure the proper regulation of the DNA dependent processes. To achieve this, chromatin remodeling complexes harbor protein domains that specifically read chromatin targeting signals, such as histone modifications, DNA sequence/structure, non-coding RNAs, histone variants or DNA bound interacting proteins. Recent studies reveal the interaction between non-coding RNAs and chromatin remodeling complexes showing importance of RNA in remodeling enzyme targeting, scaffolding and regulation. In this review, we summarize current understanding of chromatin remodeling enzyme targeting to chromatin and their role in cancer development. View Full-Text
Keywords: chromatin remodeler; cancer; search mechanism; arrest model; non-coding RNA chromatin remodeler; cancer; search mechanism; arrest model; non-coding RNA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Längst, G.; Manelyte, L. Chromatin Remodelers: From Function to Dysfunction. Genes 2015, 6, 299-324.

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