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Genes 2014, 5(1), 65-83; doi:10.3390/genes5010065
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The Genomic Signature of Breast Cancer Prevention

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Received: 18 December 2013; in revised form: 31 January 2014 / Accepted: 8 February 2014 / Published: 26 February 2014
(This article belongs to the Special Issue Grand Celebration: 10th Anniversary of the Human Genome Project)
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Abstract: The breast of parous postmenopausal women exhibits a specific signature that has been induced by a full term pregnancy. This signature is centered in chromatin remodeling and the epigenetic changes induced by methylation of specific genes which are important regulatory pathways induced by pregnancy. Through the analysis of the genes found to be differentially methylated between women of varying parity, multiple positions at which beta-catenin production and use is inhibited were recognized. The biological importance of the pathways identified in this specific population cannot be sufficiently emphasized because they could represent a safeguard mechanism mediating the protection of the breast conferred by full term pregnancy.
Keywords: normal breast; breast cancer; genomic signature; prevention; pregnancy; splicing mechanisms; methylation; chromatin remodeling; Lnc-RNA; beta-catenin normal breast; breast cancer; genomic signature; prevention; pregnancy; splicing mechanisms; methylation; chromatin remodeling; Lnc-RNA; beta-catenin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Russo, J.; Santucci-Pereira, J.; Russo, I.H. The Genomic Signature of Breast Cancer Prevention. Genes 2014, 5, 65-83.

AMA Style

Russo J, Santucci-Pereira J, Russo IH. The Genomic Signature of Breast Cancer Prevention. Genes. 2014; 5(1):65-83.

Chicago/Turabian Style

Russo, Jose; Santucci-Pereira, Julia; Russo, Irma H. 2014. "The Genomic Signature of Breast Cancer Prevention." Genes 5, no. 1: 65-83.


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