Next Article in Journal / Special Issue
Next Generation Sequence Analysis and Computational Genomics Using Graphical Pipeline Workflows
Previous Article in Journal
Regulation of Fibroblast Growth Factor-2 Expression and Cell Cycle Progression by an Endogenous Antisense RNA
Previous Article in Special Issue
REGEN: Ancestral Genome Reconstruction for Bacteria
Genes 2012, 3(3), 521-544; doi:10.3390/genes3030521
Review

Radiobiology and Reproduction—What Can We Learn from Mammalian Females?

1,2,* , 3
 and 1,2,*
Received: 20 June 2012; in revised form: 9 August 2012 / Accepted: 13 August 2012 / Published: 27 August 2012
(This article belongs to the Special Issue Feature Paper 2012)
View Full-Text   |   Download PDF [292 KB, uploaded 27 August 2012]   |   Browse Figures
Abstract: Ionizing radiation damages DNA and induces mutations as well as chromosomal reorganizations. Although radiotherapy increases survival among cancer patients, this treatment does not come without secondary effects, among which the most problematic is gonadal dysfunction, especially in women. Even more, if radio-induced DNA damage occurs in germ cells during spermatogenesis and/or oogenesis, they can produce chromosomal reorganizations associated with meiosis malfunction, abortions, as well as hereditary effects. However, most of our current knowledge of ionizing radiation genotoxic effects is derived from in vitro studies performed in somatic cells and there are only some experimental data that shed light on how germ cells work when affected by DNA alterations produced by ionizing radiation. In addition, these few data are often related to mammalian males, making it difficult to extrapolate the results to females. Here, we review the current knowledge of radiobiology and reproduction, paying attention to mammalian females. In order to do that, we will navigate across the female meiotic/reproductive cycle/life taking into account the radiation-induced genotoxic effects analysis and animal models used, published in recent decades.
Keywords: meiosis; oocytes; fertility; ionizing irradiation effects; radiation-sensitivity; DSBs; genome instability meiosis; oocytes; fertility; ionizing irradiation effects; radiation-sensitivity; DSBs; genome instability
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Ruiz-Herrera, A.; Garcia, F.; Garcia-Caldés, M. Radiobiology and Reproduction—What Can We Learn from Mammalian Females? Genes 2012, 3, 521-544.

AMA Style

Ruiz-Herrera A, Garcia F, Garcia-Caldés M. Radiobiology and Reproduction—What Can We Learn from Mammalian Females? Genes. 2012; 3(3):521-544.

Chicago/Turabian Style

Ruiz-Herrera, Aurora; Garcia, Francisca; Garcia-Caldés, Montserrat. 2012. "Radiobiology and Reproduction—What Can We Learn from Mammalian Females?" Genes 3, no. 3: 521-544.


Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert