The Hexosamine Biosynthesis Pathway: Regulation and Function
Round 1
Reviewer 1 Report
In the manuscript (genes-2341668) entitled "The hexosamine biosynthesis pathway: regulation and function" in which an overview of the biosynthetic pathway of hexosamines (HBP) is offered. In addition, as the reading of the manuscript goes on, it goes deeper into the most unique molecular aspects of each of the targets involved in it. A broad sweep is also given to the pathologies that have been related to this pathway. Giving specific examples of these diseases and making a compilation of possible therapeutic approaches, both pharmacological and dietary.
So, I think the manuscript is easily understandable by GENES readers. The structure is clear and helps to understand the information presented, starting with the most general and going to the most specific.
Despite not being a very original work, I think it is a necessary and very useful work for the scientific community, since it makes a very good compilation of the existing information.
Author Response
We thank the reviewer for the positive assessment of our manuscript. We have slightly modified the abstract in response to request from reviewer 2 and corrected other typos.
Reviewer 2 Report
This excellent review of the hexosamine biosynthesis pathway. It contains thorough knowledge of the process itself, the proteins and molecules involved. The relationships between dysfunction of particular components of the hexosamine pathway with some diseases was presented excellently. I suggest to be more specific presenteing the following infomation in the Abstract:".. the regulation of the de novo and salvage HBP", "the product of the HBP is utilized for N-glycosylation to promote protein homeostasis and for O-GlcNAcylation to modulate cell signaling.", "deregulation of these functions can lead to diseases "., examples of how manipulating this pathway via pharmacological or dietary approaches can have therapeutic efficacy for diseases related to defective HBP."
Please extend also the legend to figure 1.
Author Response
We sincerely thank the reviewer for the positive assessment of our manuscript and for the helpful comments. We have now revised the abstract to provide more details as suggested by the reviewer. We also corrected typos in the whole manuscript.
