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Cells 2018, 7(8), 99; https://doi.org/10.3390/cells7080099

CEP55 Promotes Cell Motility via JAK2–STAT3–MMPs Cascade in Hepatocellular Carcinoma

1
Taishan Scholar Immunology Program, School of Basic Medical Sciences, Binzhou Medical University, Yantai 264003, China
2
Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, China
3
Departments of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
4
Department of Clinical College of Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, China
*
Author to whom correspondence should be addressed.
Received: 7 June 2018 / Revised: 2 August 2018 / Accepted: 3 August 2018 / Published: 8 August 2018
(This article belongs to the Section Cell Motility and Adhesion)
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies and has a poor prognosis. Novel diagnostic or prognostic biomarkers and potential therapeutic targets for HCC are thus urgently needed. CEP55 plays a crucial role in regulating physical cytokinesis. Whether, and how, CEP55 contributes to HCC development remains unclear. Herein, we demonstrate that CEP55 is abnormally upregulated in HCC tissue, and these high levels of CEP55 are closely related to the poor prognosis of HCC patients. Knockdown of CEP55 expression significantly inhibits HCC cell migration and invasion. We also demonstrate that CEP55 physiologically interacts with JAK2 and promotes its phosphorylation; thus, it is a novel regulator of JAK2–STAT3 signaling and its target genes MMP2/9. Finally, blocking JAK2 or STAT3 blunts the stimulation of migration and invasion due to CEP55 overexpression. In summary, our results suggest that CEP55, as an oncogene, promotes HCC cell migration and invasion through regulating JAK2–STAT3–MMPs signaling. View Full-Text
Keywords: CEP55; hepatocellular carcinoma; JAK2-STAT3; migration; invasion CEP55; hepatocellular carcinoma; JAK2-STAT3; migration; invasion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, M.; Gao, J.; Li, D.; Yin, Y. CEP55 Promotes Cell Motility via JAK2–STAT3–MMPs Cascade in Hepatocellular Carcinoma. Cells 2018, 7, 99.

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