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Cells 2018, 7(8), 100; https://doi.org/10.3390/cells7080100

Predicting MicroRNA Mediated Gene Regulation between Human and Viruses

The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210023, China
These authors contributed equally to this work as first authors.
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Received: 26 June 2018 / Revised: 2 August 2018 / Accepted: 6 August 2018 / Published: 8 August 2018
(This article belongs to the Special Issue Regulatory microRNA)
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Abstract

MicroRNAs (miRNAs) mediate various biological processes by actively fine-tuning gene expression at the post-transcriptional level. With the identification of numerous human and viral miRNAs, growing evidence has indicated a common role of miRNAs in mediating the interactions between humans and viruses. However, there is only limited information about Cross-Kingdom miRNA target sites from studies. To facilitate an extensive investigation on the interplay among the gene regulatory networks of humans and viruses, we designed a prediction pipeline, mirTarP, that is suitable for miRNA target screening on the genome scale. By applying mirTarP, we constructed the database mirTar, which is a comprehensive miRNA target repository of bidirectional interspecies regulation between viruses and humans. To provide convenient downloading for users from both the molecular biology field and medical field, mirTar classifies viruses according to “ICTV viral category” and the “medical microbiology classification” on the web page. The mirTar database and mirTarP tool are freely available online. View Full-Text
Keywords: miRNA; virus; host; Cross-Kingdom; target prediction miRNA; virus; host; Cross-Kingdom; target prediction
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Shu, X.; Zang, X.; Liu, X.; Yang, J.; Wang, J. Predicting MicroRNA Mediated Gene Regulation between Human and Viruses. Cells 2018, 7, 100.

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