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Cells 2018, 7(8), 89; https://doi.org/10.3390/cells7080089

New Insights into the Occurrence of Matrix Metalloproteases -2 and -9 in a Cohort of Breast Cancer Patients and Proteomic Correlations

1
Centro di Oncobiologia Sperimentale, Università di Palermo, 90146 Palermo, Italy
2
La Maddalena Hospital, 90146 Palermo, Italy
3
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università di Palermo, 90100 Palermo, Italy
*
Authors to whom correspondence should be addressed.
Received: 8 June 2018 / Revised: 19 July 2018 / Accepted: 24 July 2018 / Published: 28 July 2018
(This article belongs to the Special Issue Extracellular Matrix Remodeling)
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Abstract

Matrix metalloproteases (MMPs) are a family of well-known enzymes which operate prevalently in the extracellular domain, where they fulfil the function of remodeling the extracellular matrix (ECM). Within the 26 family members, encoded by 24 genes in humans, MMP-2 and MMP-9 have been regarded as primarily responsible for the basement membrane and peri-cellular ECM rearrangement. In cases of infiltrating carcinomas, which arise from the epithelial tissues of a gland or of an internal organ, a marked alteration of the expression and the activity levels of both MMPs is known to occur. The present investigation represents the continuation and upgrading of our previous studies, now focusing on the occurrence and intensity levels of MMP-2 and -9 and their proteomic correlations in a cohort of 80 breast cancer surgical tissues. View Full-Text
Keywords: matrix metalloproteases; breast cancer; proteomics matrix metalloproteases; breast cancer; proteomics
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Di Cara, G.; Marabeti, M.R.; Musso, R.; Riili, I.; Cancemi, P.; Pucci Minafra, I. New Insights into the Occurrence of Matrix Metalloproteases -2 and -9 in a Cohort of Breast Cancer Patients and Proteomic Correlations. Cells 2018, 7, 89.

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