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Cells 2018, 7(8), 109; https://doi.org/10.3390/cells7080109

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Goethestr. 33, 80336 Munich, Germany
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Received: 13 July 2018 / Revised: 13 August 2018 / Accepted: 13 August 2018 / Published: 17 August 2018
(This article belongs to the Special Issue TRP Channels in Health and Disease)
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Abstract

The enzyme-coupled transient receptor potential channel subfamily M member 7, TRPM7, has been associated with immunity and immune cell signalling. Here, we review the role of this remarkable signalling protein in lymphocyte proliferation, differentiation, activation and survival. We also discuss its role in mast cell, neutrophil and macrophage function and highlight the potential of TRPM7 to regulate immune system homeostasis. Further, we shed light on how the cellular signalling cascades involving TRPM7 channel and/or kinase activity culminate in pathologies as diverse as allergic hypersensitivity, arterial thrombosis and graft versus host disease (GVHD), stressing the need for TRPM7 specific pharmacological modulators. View Full-Text
Keywords: TRPM7; kinase; inflammation; lymphocytes; calcium signalling; SMAD; TH17; hypersensitivity; regulatory T cells; thrombosis; graft versus host disease TRPM7; kinase; inflammation; lymphocytes; calcium signalling; SMAD; TH17; hypersensitivity; regulatory T cells; thrombosis; graft versus host disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Nadolni, W.; Zierler, S. The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis. Cells 2018, 7, 109.

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