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Cells 2018, 7(5), 40; https://doi.org/10.3390/cells7050040

Alterations of Oxidative Phosphorylation Complexes in Papillary Thyroid Carcinoma

1
Research Program for Receptor Biochemistry and Tumor Metabolism, University Hospital Salzburg, Paracelsus Medical University, Salzburg 5020, Austria
2
Department of Pathology, University Hospital Salzburg, Paracelsus Medical University, Salzburg 5020, Austria
3
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg 5020, Austria
*
Authors to whom correspondence should be addressed.
Received: 9 April 2018 / Revised: 3 May 2018 / Accepted: 7 May 2018 / Published: 9 May 2018
(This article belongs to the Special Issue Mitochondrial Bioenergetics in Cancer Cell Biology)
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Abstract

The papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland, with disruptive mutations in mitochondrial complex I subunits reported at very low frequency. Furthermore, metabolic diversity of PTC has been postulated owing to variable messenger RNA (mRNA) expression of genes encoding subunits of the oxidative phosphorylation (OXHPOS) complexes. The aim of the present study was to evaluate the metabolic diversity of the OXPHOS system at the protein level by using immunohistochemical staining. Analysis of 18 human PTCs revealed elevated mitochondrial biogenesis but significantly lower levels of OXPHOS complex I in the tumor tissue (p < 0.0001) compared to the adjacent normal tissue. In contrast, OXPHOS complexes II–V were increased in the majority of PTCs. In three PTCs, we found pathologic mutations within mitochondrially encoded complex I subunits. Our data indicate that PTCs are characterized by an oncocytic metabolic signature that is in low complex I is combined with elevated mitochondrial mass and high complex II–V levels, which might be an important factor for tumor formation. View Full-Text
Keywords: papillary thyroid carcinoma; mitochondria; respiratory chain complex I papillary thyroid carcinoma; mitochondria; respiratory chain complex I
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Zimmermann, F.A.; Neureiter, D.; Sperl, W.; Mayr, J.A.; Kofler, B. Alterations of Oxidative Phosphorylation Complexes in Papillary Thyroid Carcinoma. Cells 2018, 7, 40.

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