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Cells 2018, 7(5), 34; https://doi.org/10.3390/cells7050034

Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae)

1
Department of Cell and Development Biology, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL), Gabriel Monteiro da Silva 700, 37130-001 Alfenas-MG, Brazil
2
Department of Morphology, Botucatu Biosciences Institute, State University of São Paulo (UNESP), Prof. Dr. Antonio Celso Wagner Zanin 250, 18618-689 Botucatu-SP, Brazil
3
Department of Biodiversity and Experimental Biology, Faculty of Exact and Natural Sciences, Ciudad Universitaria, Lab. 4 y 78; Piso 4to., Pabellón 2, Int. Güiraldes 2160, C1428EGA Buenos Aires, Argentina
4
Institute of Biology, UNICAMP, Bertrand Russel s/n, 13083-865 Campinas-SP, Brazil
5
Aquaculture Center of UNESP (CAUNESP), Prof. Paulo Donato Castellane s/n, 14884-900 Jaboticabal-SP, Brazil
*
Author to whom correspondence should be addressed.
Received: 23 February 2018 / Revised: 14 April 2018 / Accepted: 19 April 2018 / Published: 24 April 2018
(This article belongs to the Special Issue Extracellular Matrix Remodeling)
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Abstract

Teleostei present great plasticity regarding sex change. During sex reversal, the whole gonad including the germinal epithelium undergoes significant changes, remodeling, and neoformation. However, there is no information on the changes that occur within the interstitial compartment. Considering the lack of information, especially on the role played by metalloproteinases (MMPs) in fish gonadal remodeling, the aim of this study was to evaluate the action of MMPs on gonads of sex reversed females of Synbranchus marmoratus, a fresh water protogynic diandric fish. Gonads were processed for light microscopy and blood samples were used for the determination of plasma sex steroid levels. During sex reversal, degeneration of the ovaries occurred and were gradually replaced by the germinal tissue of the male. The action of the MMPs induces significant changes in the interstitial compartment, allowing the reorganization of germinal epithelium. Leydig cells also showed an important role in female to male reversion. The gonadal transition coincides with changes in circulating sex steroid levels throughout sex reversion. The action of the MMPs, in the gonadal remodeling, especially on the basement membrane, is essential for the establishment of a new functional germinal epithelium. View Full-Text
Keywords: extracellular matrix; collagenase; protogynous diandric fish; germinal epithelium; gonad extracellular matrix; collagenase; protogynous diandric fish; germinal epithelium; gonad
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Mazzoni, T.S.; Lo Nostro, F.L.; Antoneli, F.N.; Quagio-Grassiotto, I. Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae). Cells 2018, 7, 34.

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