Next Article in Journal
Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?
Previous Article in Journal
Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessReview
Cells 2017, 6(4), 43; doi:10.3390/cells6040043

Danger: High Voltage—The Role of Voltage-Gated Calcium Channels in Central Nervous System Pathology

1
Institute of Anatomy and Cell Biology, University of Würzburg, 97070 Würzburg, Germany
2
Institute of Anatomy and Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Received: 14 September 2017 / Revised: 10 November 2017 / Accepted: 13 November 2017 / Published: 15 November 2017
View Full-Text   |   Download PDF [896 KB, uploaded 16 November 2017]   |  

Abstract

Voltage-gated calcium channels (VGCCs) are widely distributed within the central nervous system (CNS) and presumed to play an important role in the pathophysiology of a broad spectrum of CNS disorders including Alzheimer’s and Parkinson’s disease as well as multiple sclerosis. Several calcium channel blockers have been in clinical practice for many years so that their toxicity and side effects are well studied. However, these drugs are primarily used for the treatment of cardiovascular diseases and most if not all effects on brain functions are secondary to peripheral effects on blood pressure and circulation. While the use of calcium channel antagonists for the treatment of CNS diseases therefore still heavily depends on the development of novel strategies to specifically target different channels and channel subunits, this review is meant to provide an impulse to further emphasize the importance of future research towards this goal. View Full-Text
Keywords: calcium; calcium channel antagonists; CNS; EAE; neurodegeneration; MS; regeneration; remyelination calcium; calcium channel antagonists; CNS; EAE; neurodegeneration; MS; regeneration; remyelination
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Schampel, A.; Kuerten, S. Danger: High Voltage—The Role of Voltage-Gated Calcium Channels in Central Nervous System Pathology. Cells 2017, 6, 43.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top