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Cells 2016, 5(4), 42; doi:10.3390/cells5040042

The Role and Application of Sirtuins and mTOR Signaling in the Control of Ovarian Functions

Department of Zoology and Anthropology, Constantine the Philosopher University, 94974 Nitra, Slovakia
Research Institute of Animal Production, 941 51 Lužianky, Slovakia
Academic Editor: Bor Luen Tang
Received: 30 July 2016 / Revised: 3 November 2016 / Accepted: 4 November 2016 / Published: 24 November 2016
(This article belongs to the Special Issue Sirtuins in Aging and Diseases)
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The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of ovarian functions at various regulatory levels. External and endocrine factors can affect female reproduction via SIRTs-mammalian target of rapamycin (mTOR) system, which, via hormones and growth factors, can in turn regulate basic ovarian functions (proliferation, apoptosis, secretory activity of ovarian cells, their response to upstream hormonal regulators, ovarian folliculo- and oogenesis, and fecundity). SIRTs and SIRTs-related signaling molecules and drugs regulating mTOR can be used for characterization, prediction, and regulation of ovarian functions, as well as for diagnostics and treatment of ovarian disorders. View Full-Text
Keywords: sirtuin; mTOR; ovary; proliferation; apoptosis; hormones; folliculogenesis; cancer sirtuin; mTOR; ovary; proliferation; apoptosis; hormones; folliculogenesis; cancer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sirotkin, A.V. The Role and Application of Sirtuins and mTOR Signaling in the Control of Ovarian Functions. Cells 2016, 5, 42.

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