Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies
AbstractLamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism. Numerous mutations in A-type lamins cause a plethora of diverse diseases collectively termed as laminopathies, the majority of which are characterized by irregularly shaped, fragile, and plastic nuclei. These nuclei are challenged to normal mechanotransduction and lead to disease phenotypes. Here, we review our current understanding of the nucleocytoskeleton coupling in mechanotransduction mediated by lamins. We also present an up-to-date understanding of the methods used to determine laminar elasticity both at the bulk and single molecule level. View Full-Text
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Dutta, S.; Bhattacharyya, M.; Sengupta, K. Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies. Cells 2016, 5, 37.
Dutta S, Bhattacharyya M, Sengupta K. Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies. Cells. 2016; 5(4):37.Chicago/Turabian Style
Dutta, Subarna; Bhattacharyya, Maitree; Sengupta, Kaushik. 2016. "Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies." Cells 5, no. 4: 37.
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