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Cells 2016, 5(4), 37; doi:10.3390/cells5040037

Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies

1
Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, West Bengal, India
2
Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Dechat
Received: 6 September 2016 / Revised: 28 September 2016 / Accepted: 10 October 2016 / Published: 14 October 2016
(This article belongs to the Collection Lamins and Laminopathies)
View Full-Text   |   Download PDF [583 KB, uploaded 14 October 2016]   |  

Abstract

Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism. Numerous mutations in A-type lamins cause a plethora of diverse diseases collectively termed as laminopathies, the majority of which are characterized by irregularly shaped, fragile, and plastic nuclei. These nuclei are challenged to normal mechanotransduction and lead to disease phenotypes. Here, we review our current understanding of the nucleocytoskeleton coupling in mechanotransduction mediated by lamins. We also present an up-to-date understanding of the methods used to determine laminar elasticity both at the bulk and single molecule level. View Full-Text
Keywords: lamins; mechanotransduction; elasticity; single molecule force spectroscopy lamins; mechanotransduction; elasticity; single molecule force spectroscopy
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Dutta, S.; Bhattacharyya, M.; Sengupta, K. Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies. Cells 2016, 5, 37.

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