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Cells 2016, 5(3), 34; doi:10.3390/cells5030034

Multiple Roles of the Small GTPase Rab7

Department of Biological and Environmental Sciences and Technologies (DiSTeBA), Università del Salento, Via Provinciale Lecce-Monteroni n. 165, 73100 Lecce, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Bor Luen Tang
Received: 25 May 2016 / Revised: 11 August 2016 / Accepted: 12 August 2016 / Published: 18 August 2016
(This article belongs to the Special Issue Regulation and Function of Small GTPases)
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Abstract

Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied. Rab7 is fundamental for lysosomal biogenesis, positioning and functions, and for trafficking and degradation of several signaling receptors, thus also having implications on signal transduction. Several Rab7 interacting proteins have being identified leading to the discovery of a number of different important functions, beside its established role in endocytosis. Furthermore, Rab7 has specific functions in neurons. This review highlights and discusses the role and the importance of Rab7 on different cellular pathways and processes. View Full-Text
Keywords: Rab7; endocytosis; vesicular transport; membrane traffic; lysosome; autophagy; mitophagy; lipophagy; apoptosis; intermediate filaments Rab7; endocytosis; vesicular transport; membrane traffic; lysosome; autophagy; mitophagy; lipophagy; apoptosis; intermediate filaments
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guerra, F.; Bucci, C. Multiple Roles of the Small GTPase Rab7. Cells 2016, 5, 34.

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