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Cells 2016, 5(3), 30; doi:10.3390/cells5030030

Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function

Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Wendlingweg 2, Aachen 52074, Germany
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Academic Editor: Alexander E. Kalyuzhny
Received: 2 May 2016 / Revised: 24 June 2016 / Accepted: 30 June 2016 / Published: 5 July 2016
(This article belongs to the Special Issue Beyond Cell Mechanics: Novel Functions of Intermediate Filaments)
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Abstract

Intermediate filaments together with actin filaments and microtubules form the cytoskeleton, which is a complex and highly dynamic 3D network. Intermediate filaments are the major mechanical stress protectors but also affect cell growth, differentiation, signal transduction, and migration. Using intermediate filament-mitochondrial crosstalk as a prominent example, this review emphasizes the importance of intermediate filaments as crucial organizers of cytoplasmic space to support these functions. We summarize observations in different mammalian cell types which demonstrate how intermediate filaments influence mitochondrial morphology, subcellular localization, and function through direct and indirect interactions and how perturbations of these interactions may lead to human diseases. View Full-Text
Keywords: mitochondrion; mitochondria-associated membrane; intermediate filament; neurofilament; desmin; keratin; vimentin mitochondrion; mitochondria-associated membrane; intermediate filament; neurofilament; desmin; keratin; vimentin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Schwarz, N.; Leube, R.E. Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function. Cells 2016, 5, 30.

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