The Ubiquitination of NF-κB Subunits in the Control of Transcription
AbstractNuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors fundamental in the control of the inflammatory response. The transcription of hundreds of genes involved in inflammation and immune homeostasis require NF-κB, necessitating the need for its strict control. The inducible ubiquitination and proteasomal degradation of the cytoplasmic inhibitor of κB (IκB) proteins promotes the nuclear translocation and transcriptional activity of NF-κB. More recently, an additional role for ubiquitination in the regulation of NF-κB activity has been identified. In this case, the ubiquitination and degradation of the NF-κB subunits themselves plays a critical role in the termination of NF-κB activity and the associated transcriptional response. While there is still much to discover, a number of NF-κB ubiquitin ligases and deubiquitinases have now been identified which coordinate to regulate the NF-κB transcriptional response. This review will focus the regulation of NF-κB subunits by ubiquitination, the key regulatory components and their impact on NF-κB directed transcription. View Full-Text
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Collins, P.E.; Mitxitorena, I.; Carmody, R.J. The Ubiquitination of NF-κB Subunits in the Control of Transcription. Cells 2016, 5, 23.
Collins PE, Mitxitorena I, Carmody RJ. The Ubiquitination of NF-κB Subunits in the Control of Transcription. Cells. 2016; 5(2):23.Chicago/Turabian Style
Collins, Patricia E.; Mitxitorena, Izaskun; Carmody, Ruaidhrí J. 2016. "The Ubiquitination of NF-κB Subunits in the Control of Transcription." Cells 5, no. 2: 23.
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