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Cells 2016, 5(2), 22; doi:10.3390/cells5020022

Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions

NF-κB, Differentiation and Cancer, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France
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Academic Editor: Ruaidhri Carmody
Received: 11 March 2016 / Revised: 19 April 2016 / Accepted: 26 April 2016 / Published: 4 May 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
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Abstract

The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development. Beyond the classical NF-κB activation pathway, a second NF-κB pathway has more recently been uncovered, the so-called alternative NF-κB activation pathway. It has been shown that this pathway mainly controls the activity of RelB, a member of the NF-κB family. Post-translational modifications, such as phosphorylation, acetylation, methylation, ubiquitination and SUMOylation, have recently emerged as a strategy for the fine-tuned regulation of NF-κB. Our review discusses recent progress in the understanding of RelB regulation by post-translational modifications and the associated functions in normal and pathological conditions. View Full-Text
Keywords: NF-kappaB; RelB; post-translational modifications; cell motility; phosphorylation; ubiquitination; SUMOylation; NF-κB alternative pathway NF-kappaB; RelB; post-translational modifications; cell motility; phosphorylation; ubiquitination; SUMOylation; NF-κB alternative pathway
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Baud, V.; Collares, D. Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions. Cells 2016, 5, 22.

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