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Cells 2015, 4(3), 253-274; doi:10.3390/cells4030253

The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology

1
Human Health Therapeutics, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada
2
Histology & Embryology Unit, Department of Life & Reproduction Sciences, University of Verona Medical School, 8 Strada Le Grazie, Verona, Venetia 37134, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Gang Dong and William Tsang
Received: 19 May 2015 / Revised: 18 June 2015 / Accepted: 6 July 2015 / Published: 13 July 2015
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
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Abstract

Dentate-gyral granule cells in the hippocampus plus dentate gyrus memory-recording/retrieving machine, unlike most other neurons in the brain, are continuously being generated in the adult brain with the important task of separating overlapping patterns of data streaming in from the outside world via the entorhinal cortex. This “adult neurogenesis” is driven by tools in the mature granule cell’s cilium. Here we report our discovery of leptin’s LepRb receptor in this cilium. In addition, we discuss how ciliary LepRb signaling might be involved with ciliary p75NTR and SSTR3 receptors in adult neurogenesis and memory formation as well as attenuation of Alzheimer’s neuropathology by reducing the production of its toxic amyloid-β-derived drivers. View Full-Text
Keywords: adult neurogenesis; Alzheimer’s disease; amyloid-β; amyloid-β oligomers; ciliary LepRb; dentate gyrus; hippocampus; hyperphosphorylated tau; leptin; memory formation; p75NTR; somatostatin receptor adult neurogenesis; Alzheimer’s disease; amyloid-β; amyloid-β oligomers; ciliary LepRb; dentate gyrus; hippocampus; hyperphosphorylated tau; leptin; memory formation; p75NTR; somatostatin receptor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Whitfield, J.F.; Chiarini, A.; Dal Prà, I.; Armato, U.; Chakravarthy, B. The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology. Cells 2015, 4, 253-274.

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