Next Article in Journal / Special Issue
Cyclic GMP and Cilia Motility
Previous Article in Journal
Misdelivery at the Nuclear Pore Complex—Stopping a Virus Dead in Its Tracks
Previous Article in Special Issue
The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology
Article Menu

Export Article

Open AccessReview
Cells 2015, 4(3), 297-314; doi:10.3390/cells4030297

Novel Insights into the Development and Function of Cilia Using the Advantages of the Paramecium Cell and Its Many Cilia

Department of Biology, University of Vermont, Burlington, VT 05405, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Gang Dong and William Tsang
Received: 29 May 2015 / Revised: 16 July 2015 / Accepted: 24 July 2015 / Published: 29 July 2015
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
View Full-Text   |   Download PDF [3054 KB, uploaded 29 July 2015]   |  

Abstract

Paramecium species, especially P. tetraurelia and caudatum, are model organisms for modern research into the form and function of cilia. In this review, we focus on the ciliary ion channels and other transmembrane proteins that control the beat frequency and wave form of the cilium by controlling the signaling within the cilium. We put these discussions in the context of the advantages that Paramecium brings to the understanding of ciliary motility: mutants for genetic dissections of swimming behavior, electrophysiology, structural analysis, abundant cilia for biochemistry and modern proteomics, genomics and molecular biology. We review the connection between behavior and physiology, which allows the cells to broadcast the function of their ciliary channels in real time. We build a case for the important insights and advantages that this model organism continues to bring to the study of cilia. View Full-Text
Keywords: Paramecium; cilia; calcium; signal transduction; swimming behavior; electrophysiology; proteomics Paramecium; cilia; calcium; signal transduction; swimming behavior; electrophysiology; proteomics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yano, J.; Valentine, M.S.; Van Houten, J.L. Novel Insights into the Development and Function of Cilia Using the Advantages of the Paramecium Cell and Its Many Cilia. Cells 2015, 4, 297-314.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top