A correction was published on 20 June 2014, see Cells 2014, 3(2), 660-661.

Cells 2014, 3(1), 112-128; doi:10.3390/cells3010112

Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression

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Received: 19 December 2013; in revised form: 22 January 2014 / Accepted: 8 February 2014 / Published: 19 February 2014
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs), in development and progression of different tumor types. In normal cells, the activation of TRPV2 channels by growth factors, hormones, and endocannabinoids induces a translocation of the receptor from the endosomal compartment to the plasma membrane, which results in abrogation of cell proliferation and induction of cell death. Consequently, loss or inactivation of TRPV2 signaling (e.g., glioblastomas), induces unchecked proliferation, resistance to apoptotic signals and increased resistance to CD95-induced apoptotic cell death. On the other hand, in prostate cancer cells, Ca2+-dependent activation of TRPV2 induced by lysophospholipids increases the invasion of tumor cells. In addition, the progression of prostate cancer to the castration-resistant phenotype is characterized by de novo TRPV2 expression, with higher TRPV2 transcript levels in patients with metastatic cancer. Finally, TRPV2 functional expression in tumor cells can also depend on the presence of alternative splice variants of TRPV2 mRNA that act as dominant-negative mutant of wild-type TRPV2 channels, by inhibiting its trafficking and translocation to the plasma membrane. In conclusion, as TRP channels are altered in human cancers, and their blockage impair tumor progression, they appear to be a very promising targets for early diagnosis and chemotherapy.
Keywords: Transient Receptor Potential Channels; Transient Receptor Potential Vanilloid-type 2; tumor progression; glioblastoma; prostate cancer; transitional cell carcinoma of human bladder; hepatocarcinoma
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MDPI and ACS Style

Liberati, S.; Morelli, M.B.; Amantini, C.; Farfariello, V.; Santoni, M.; Conti, A.; Nabissi, M.; Cascinu, S.; Santoni, G. Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression. Cells 2014, 3, 112-128.

AMA Style

Liberati S, Morelli MB, Amantini C, Farfariello V, Santoni M, Conti A, Nabissi M, Cascinu S, Santoni G. Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression. Cells. 2014; 3(1):112-128.

Chicago/Turabian Style

Liberati, Sonia; Morelli, Maria B.; Amantini, Consuelo; Farfariello, Valerio; Santoni, Matteo; Conti, Alessandro; Nabissi, Massimo; Cascinu, Stefano; Santoni, Giorgio. 2014. "Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression." Cells 3, no. 1: 112-128.

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