Cells 2013, 2(4), 732-750; doi:10.3390/cells2040732
Review

Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles

Department of Biological Sciences, Tokyo Institute of Technology, 4259-B13 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan
Received: 7 October 2013; in revised form: 12 November 2013 / Accepted: 29 November 2013 / Published: 5 December 2013
(This article belongs to the Special Issue Protein Ubiquitination)
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Abstract: It is now understood that protein ubiquitination has diverse cellular functions in eukaryotes. The molecular mechanism and physiological significance of ubiquitin-mediated processes have been extensively studied in yeast, Drosophila and mammalian somatic cells. Moreover, an increasing number of studies have emphasized the importance of ubiquitination in spermatogenesis and fertilization. The dysfunction of various ubiquitin systems results in impaired sperm development with abnormal organelle morphology and function, which in turn is highly associated with male infertility. This review will focus on the emerging roles of ubiquitination in biogenesis, function and stability of sperm organelles in mammals.
Keywords: acrosome; deubiquitination; histone; membrane trafficking; mitochondria; mitophagy; spermatogenesis; spermiogenesis; ubiquitination

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MDPI and ACS Style

Nakamura, N. Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles. Cells 2013, 2, 732-750.

AMA Style

Nakamura N. Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles. Cells. 2013; 2(4):732-750.

Chicago/Turabian Style

Nakamura, Nobuhiro. 2013. "Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles." Cells 2, no. 4: 732-750.

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