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Cells 2013, 2(2), 294-305; doi:10.3390/cells2020294
Review

Morphological Features of Organelles during Apoptosis: An Overview

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Received: 31 January 2013 / Revised: 24 March 2013 / Accepted: 19 April 2013 / Published: 8 May 2013
(This article belongs to the Special Issue Apoptosis)
View Full-Text   |   Download PDF [637 KB, 13 May 2013; original version 8 May 2013]   |   Browse Figures

Abstract

An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear dynamics, as well as changes affecting the organelle structure and distribution. In human cancer cells driven to apoptosis by different stimuli, we have recently investigated the morphological properties of several organelles, including mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In this review, we will discuss the body of evidence in the literature suggesting that organelles are generally relocated and/or degraded during apoptosis, irrespectively of the apoptogenic stimulus and cell type.
Keywords: apoptosis; cytoskeleton; endoplasmic reticulum; Golgi apparatus; lysosomes; mitochondria apoptosis; cytoskeleton; endoplasmic reticulum; Golgi apparatus; lysosomes; mitochondria
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bottone, M.G.; Santin, G.; Aredia, F.; Bernocchi, G.; Pellicciari, C.; Scovassi, A.I. Morphological Features of Organelles during Apoptosis: An Overview. Cells 2013, 2, 294-305.

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