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Morphological Features of Organelles during Apoptosis: An Overview
Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, 27100 Pavia, Italy
Istituto di Genetica Molecolare CNR, 27100 Pavia, Italy
* Author to whom correspondence should be addressed.
Received: 31 January 2013; in revised form: 24 March 2013 / Accepted: 19 April 2013 / Published: 8 May 2013
(This article belongs to the Special Issue Apoptosis
Abstract: An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear dynamics, as well as changes affecting the organelle structure and distribution. In human cancer cells driven to apoptosis by different stimuli, we have recently investigated the morphological properties of several organelles, including mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In this review, we will discuss the body of evidence in the literature suggesting that organelles are generally relocated and/or degraded during apoptosis, irrespectively of the apoptogenic stimulus and cell type.
Keywords: apoptosis; cytoskeleton; endoplasmic reticulum; Golgi apparatus; lysosomes; mitochondria
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Bottone, M.G.; Santin, G.; Aredia, F.; Bernocchi, G.; Pellicciari, C.; Scovassi, A.I. Morphological Features of Organelles during Apoptosis: An Overview. Cells 2013, 2, 294-305.
Bottone MG, Santin G, Aredia F, Bernocchi G, Pellicciari C, Scovassi AI. Morphological Features of Organelles during Apoptosis: An Overview. Cells. 2013; 2(2):294-305.
Bottone, Maria G.; Santin, Giada; Aredia, Francesca; Bernocchi, Graziella; Pellicciari, Carlo; Scovassi, Anna I. 2013. "Morphological Features of Organelles during Apoptosis: An Overview." Cells 2, no. 2: 294-305.