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The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress
Institut National de la Santé et de la Recherche Médicale (Inserm), UMR866, Dijon F-21079, France
Institut Fédératif de Recherche (IFR), Université de Bourgogne, 100, Dijon F-21079, France
Ecole Pratique des Hautes Etudes (EPHE) EA 7269, Dijon, F-21079, France
* Author to whom correspondence should be addressed.
Received: 31 July 2012; in revised form: 14 September 2012 / Accepted: 27 September 2012 / Published: 10 October 2012
Abstract: Cells are constantly exposed to endogenous and exogenous cellular injuries. They cope with stressful stimuli by adapting their metabolism and activating various “guardian molecules.” These pro-survival factors protect essential cell constituents, prevent cell death, and possibly repair cellular damages. The Inhibitor of Apoptosis (IAPs) proteins display both anti-apoptotic and pro-survival properties and their expression can be induced by a variety of cellular stress such as hypoxia, endoplasmic reticular stress and DNA damage. Thus, IAPs can confer tolerance to cellular stress. This review presents the anti-apoptotic and survival functions of IAPs and their role in the adaptive response to cellular stress. The involvement of IAPs in human physiology and diseases in connection with a breakdown of cellular homeostasis will be discussed.
Keywords: IAPs; apoptosis; caspases; NF-kB; TNFR; UPR; DNA damage response; cancer; neurodegenerative disease
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MDPI and ACS Style
Marivin, A.; Berthelet, J.; Plenchette, S.; Dubrez, L. The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress. Cells 2012, 1, 711-737.
Marivin A, Berthelet J, Plenchette S, Dubrez L. The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress. Cells. 2012; 1(4):711-737.
Marivin, Arthur; Berthelet, Jean; Plenchette, Stéphanie; Dubrez, Laurence. 2012. "The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress." Cells 1, no. 4: 711-737.