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Cells 2012, 1(4), 1182-1196; doi:10.3390/cells1041182
Review

Genetic Systems to Investigate Regulation of Oncogenes and Tumour Suppressor Genes in Drosophila

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Received: 26 October 2012; in revised form: 12 November 2012 / Accepted: 28 November 2012 / Published: 5 December 2012
(This article belongs to the Special Issue Imaging in Cell Biology and Development)
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Abstract: Animal growth requires coordination of cell growth and cell cycle progression with developmental signaling. Loss of cell cycle control is extremely detrimental, with reduced cycles leading to impaired organ growth and excessive proliferation, potentially resulting in tissue overgrowth and driving tumour initiation. Due to the high level of conservation between the cell cycle machinery of Drosophila and humans, the appeal of the fly model continues to be the means with which we can use sophisticated genetics to provide novel insights into mammalian growth and cell cycle control. Over the last decade, there have been major additions to the genetic toolbox to study development in Drosophila. Here we discuss some of the approaches available to investigate the potent growth and cell cycle properties of the Drosophila counterparts of prominent cancer genes, with a focus on the c-Myc oncoprotein and the tumour suppressor protein FIR (Hfp in flies), which behaves as a transcriptional repressor of c-Myc.
Keywords: Drosophila; genetics; cell cycle; development; growth Drosophila; genetics; cell cycle; development; growth
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lee, J.E.A.; Cranna, N.J.; Chahal, A.S.; Quinn, L.M. Genetic Systems to Investigate Regulation of Oncogenes and Tumour Suppressor Genes in Drosophila. Cells 2012, 1, 1182-1196.

AMA Style

Lee JEA, Cranna NJ, Chahal AS, Quinn LM. Genetic Systems to Investigate Regulation of Oncogenes and Tumour Suppressor Genes in Drosophila. Cells. 2012; 1(4):1182-1196.

Chicago/Turabian Style

Lee, Jue E.A.; Cranna, Nicola J.; Chahal, Arjun S.; Quinn, Leonie M. 2012. "Genetic Systems to Investigate Regulation of Oncogenes and Tumour Suppressor Genes in Drosophila." Cells 1, no. 4: 1182-1196.



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