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The Anti-Apoptotic Role of Neuroglobin
School of Biological Sciences, Centre for Brain Research, University of Auckland, 3a Symonds Street, Auckland,1142, New Zealand
Received: 29 October 2012; in revised form: 15 November 2012 / Accepted: 21 November 2012 / Published: 23 November 2012
(This article belongs to the Special Issue Apoptosis
Abstract: The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c. An integrated model, based on the various molecular actions of both neuroglobin and cytochrome c, is developed, which accounts for the cellular distribution of neuroglobin.
Keywords: apoptosis; neuroglobin; neurons
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Cite This Article
MDPI and ACS Style
Brittain, T. The Anti-Apoptotic Role of Neuroglobin. Cells 2012, 1, 1133-1155.
Brittain T. The Anti-Apoptotic Role of Neuroglobin. Cells. 2012; 1(4):1133-1155.
Brittain, Thomas. 2012. "The Anti-Apoptotic Role of Neuroglobin." Cells 1, no. 4: 1133-1155.