Next Article in Journal / Special Issue
Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation
Previous Article in Journal
Intravital Microscopy Reveals Differences in the Kinetics of Endocytic Pathways between Cell Cultures and Live Animals
Cells 2012, 1(4), 1133-1155; doi:10.3390/cells1041133

The Anti-Apoptotic Role of Neuroglobin

School of Biological Sciences, Centre for Brain Research, University of Auckland, 3a Symonds Street, Auckland,1142, New Zealand
Received: 29 October 2012 / Revised: 15 November 2012 / Accepted: 21 November 2012 / Published: 23 November 2012
(This article belongs to the Special Issue Apoptosis)
View Full-Text   |   Download PDF [1163 KB, uploaded 23 November 2012]   |   Browse Figures


The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c. An integrated model, based on the various molecular actions of both neuroglobin and cytochrome c, is developed, which accounts for the cellular distribution of neuroglobin.
Keywords: apoptosis; neuroglobin; neurons apoptosis; neuroglobin; neurons
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Brittain, T. The Anti-Apoptotic Role of Neuroglobin. Cells 2012, 1, 1133-1155.

View more citation formats

Related Articles

Article Metrics


Cited By

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert