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Cells 2012, 1(4), 1133-1155; doi:10.3390/cells1041133

The Anti-Apoptotic Role of Neuroglobin

School of Biological Sciences, Centre for Brain Research, University of Auckland, 3a Symonds Street, Auckland,1142, New Zealand
Received: 29 October 2012 / Revised: 15 November 2012 / Accepted: 21 November 2012 / Published: 23 November 2012
(This article belongs to the Special Issue Apoptosis)
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The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c. An integrated model, based on the various molecular actions of both neuroglobin and cytochrome c, is developed, which accounts for the cellular distribution of neuroglobin.
Keywords: apoptosis; neuroglobin; neurons apoptosis; neuroglobin; neurons
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Brittain, T. The Anti-Apoptotic Role of Neuroglobin. Cells 2012, 1, 1133-1155.

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