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Cells 2012, 1(3), 428-448; doi:10.3390/cells1030428
Review

Autophagy During Vertebrate Development

1,2
,
3
,
1,2,4,*  and 1,2,5
1 Institute for Biomedical Research “Alberto Sols”, CSIC-UAM, C/ Arturo Duperier 4, Madrid 28029, Spain 2 Unit 761, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid 28029, Spain 3 Departamentos de Anatomía y Biología Celular, Universidad de Cantabria, Santander 39011, Spain 4 IdiPAZ, Madrid 28029, Spain 5 Departamento de Biología, Universidad Autónoma de Madrid, C/ Darwin 2, Madrid 28049, Spain
* Author to whom correspondence should be addressed.
Received: 9 May 2012 / Revised: 28 June 2012 / Accepted: 18 July 2012 / Published: 2 August 2012
(This article belongs to the Special Issue Autophagy)
View Full-Text   |   Download PDF [1037 KB, 7 August 2012; original version 2 August 2012]   |   Browse Figures

Abstract

Autophagy is an evolutionarily conserved catabolic process by which cells degrade their own components through the lysosomal machinery. In physiological conditions, the mechanism is tightly regulated and contributes to maintain a balance between synthesis and degradation in cells undergoing intense metabolic activities. Autophagy is associated with major tissue remodeling processes occurring through the embryonic, fetal and early postnatal periods of vertebrates. Here we survey current information implicating autophagy in cellular death, proliferation or differentiation in developing vertebrates. In developing systems, activation of the autophagic machinery could promote different outcomes depending on the cellular context. Autophagy is thus an extraordinary tool for the developing organs and tissues.
Keywords: autophagy; development; proliferation; apoptosis; cell differentiation; homeostasis; aging autophagy; development; proliferation; apoptosis; cell differentiation; homeostasis; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Aburto, M.R.; Hurlé, J.M.; Varela-Nieto, I.; Magariños, M. Autophagy During Vertebrate Development. Cells 2012, 1, 428-448.

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