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Polymers 2017, 9(8), 316; doi:10.3390/polym9080316

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

1
Freie Universität Berlin, Institute for Chemistry and Biochemistry, Takustraße 3, 14195 Berlin, Germany
2
DendroPharm GmbH, Arnimallee 14, 14195 Berlin, Germany
3
Chemical Materials Science, Department of Chemistry, University of Konstanz, Universitätsstraße 10, 78467 Konstanz, Germany
*
Author to whom correspondence should be addressed.
Received: 21 June 2017 / Revised: 18 July 2017 / Accepted: 25 July 2017 / Published: 29 July 2017
(This article belongs to the Special Issue Polymers and Block Copolymers at Interfaces and Surfaces)
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Abstract

We here present the synthesis and characterization of a set of biodegradable core–multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18, 19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery. View Full-Text
Keywords: biodegradable CMS nanocarrier; drug delivery; dendritic polymers; dexamethasone; tacrolimus biodegradable CMS nanocarrier; drug delivery; dendritic polymers; dexamethasone; tacrolimus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Unbehauen, M.L.; Fleige, E.; Paulus, F.; Schemmer, B.; Mecking, S.; Moré, S.D.; Haag, R. Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus. Polymers 2017, 9, 316.

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