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Polymers 2017, 9(7), 289; https://doi.org/10.3390/polym9070289

Effect of Plasticizer Type on Tensile Property and In Vitro Indomethacin Release of Thin Films Based on Low-Methoxyl Pectin

1
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
2
School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
3
ICMUB UMR CNRS 6302, University of Bourgogne Franche-Comté, 9 Avenue Alain Savary, Dijon 21000, France
4
Department of Pharmaceutical Technology, UMR PAM, Agrosup-University of Bourgogne Franche-Comté, 7 bd Jeanne d’Arc, Dijon 21079, France
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick van Rijn
Received: 7 June 2017 / Revised: 10 July 2017 / Accepted: 19 July 2017 / Published: 20 July 2017
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Abstract

This study developed the interests of low-methoxyl pectin (LMP) together with plasticizers for the preparation of elastic thin films. The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor; propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20–40% w/w) on mechanical and thermal properties of LMP films as well as on in vitro release of indomethacin were evaluated. Without any plasticizer, a brittle LMP film with low tensile strength and % elongation at break was obtained. Addition of plasticizers from 20% to 40% caused reduction in the tensile strength and Young’s modulus values, whereas percent elongation was increased. Forty percent Gly-plasticized and PG-plasticized films were selected to deliver indomethacin in comparison with non-plasticized film. No significant difference in indomethacin release profiles was displayed between the films. The analysis of indomethacin release model indicated that more than one drug release mechanism from the film formulation was involved and possibly the combination of both diffusion and erosion. Even though indomethacin incorporated in non-plasticized film showed similar release profile, Gly or PG should be added to enhanced film flexibility and decrease film brittleness. View Full-Text
Keywords: low-methoxyl pectin; indomethacin; glycerin; propylene glycol low-methoxyl pectin; indomethacin; glycerin; propylene glycol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Jantrawut, P.; Chaiwarit, T.; Jantanasakulwong, K.; Brachais, C.H.; Chambin, O. Effect of Plasticizer Type on Tensile Property and In Vitro Indomethacin Release of Thin Films Based on Low-Methoxyl Pectin. Polymers 2017, 9, 289.

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