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Polymers 2017, 9(7), 302; doi:10.3390/polym9070302

Two-Photon-Induced Microstereolithography of Chitosan-g-Oligolactides as a Function of Their Stereochemical Composition

Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences, 70 Profsoyuznaya str., Moscow 117393, Russia
Institute of Photonic Technologies, Research center “Crystallography and Photonics”, Russian Academy of Sciences, 2 Pionerskaya str., Troitsk, Moscow 142190, Russia
Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., Moscow 119991, Russia
Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina str., Moscow 119334, Russia
Author to whom correspondence should be addressed.
Received: 12 June 2017 / Revised: 20 July 2017 / Accepted: 21 July 2017 / Published: 24 July 2017
(This article belongs to the Special Issue Three-Dimensional Structures: Fabrication and Application)
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Chitosan-g-oligolactide copolymers with relatively long oligolactide grafted chains of various stereochemical compositions have been synthetized via a solvent-free mechanochemical technique and tailored to fabricate three-dimensional hydrogels using two-photon induced microstereolithography. An effect of the characteristics of chitosan and oligolactide used for the synthesis on the grafting yield and copolymer’s behavior were evaluated using fractional analysis, FTIR-spectroscopy, dynamic light scattering, and UV-spectrophotometry. The lowest copolymer yield was found for the system based on chitosan with higher molecular weight, while the samples consisting of low-molecular weight chitosan showed higher grafting degrees, which were comparable in both the cases of l,l- or l,d-oligolactide grafting. The copolymer processability in the course of two-photon stereolithography was evaluated as a function of the copolymer’s characteristics and stereolithography conditions. The structure and mechanical properties of the model film samples and fabricated 3D hydrogels were studied using optical and scanning electron microscopy, as well as by using tensile and nanoindenter devices. The application of copolymer with oligo(l,d-lactide) side chains led to higher processability during two-photon stereolithography in terms of the response to the laser beam, reproduction of the digital model, and the mechanical properties of the fabricated hydrogels. View Full-Text
Keywords: laser stereolithography; chitosan; lactide; mechanochemistry; two-photon polymerization; graft-copolymers; hydrogels laser stereolithography; chitosan; lactide; mechanochemistry; two-photon polymerization; graft-copolymers; hydrogels

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Demina, T.S.; Bardakova, K.N.; Minaev, N.V.; Svidchenko, E.A.; Istomin, A.V.; Goncharuk, G.P.; Vladimirov, L.V.; Grachev, A.V.; Zelenetskii, A.N.; Timashev, P.S.; Akopova, T.A. Two-Photon-Induced Microstereolithography of Chitosan-g-Oligolactides as a Function of Their Stereochemical Composition. Polymers 2017, 9, 302.

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