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Polymers 2017, 9(7), 280; doi:10.3390/polym9070280

Vesicles from Amphiphilic Dumbbells and Janus Dendrimers: Bioinspired Self-Assembled Structures for Biomedical Applications

1
Federal Institute for Materials Research and Testing (BAM), Department 6.0, D-12205 Berlin, Germany
2
Fraunhofer ICT-IMM, D-55129 Mainz, Germany
3
Institute of Chemistry and Biochemistry, Freie Universität Berlin, D-14195 Berlin, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Helmut Schlaad
Received: 17 May 2017 / Revised: 2 July 2017 / Accepted: 6 July 2017 / Published: 12 July 2017
(This article belongs to the Special Issue Bio-inspired and Bio-based Polymers)

Abstract

The current review focuses on vesicles obtained from the self-assembly of two types of dendritic macromolecules, namely amphiphilic Janus dendrimers (forming dendrimersomes) and amphiphilic dumbbells. In the first part, we will present some synthetic strategies and the various building blocks that can be used to obtain dendritic-based macromolecules, thereby showing their structural versatility. We put our focus on amphiphilic Janus dendrimers and amphiphilic dumbbells that form vesicles in water but we also encompass vesicles formed thereof in organic solvents. The second part of this review deals with the production methods of these vesicles at the nanoscale but also at the microscale. Furthermore, the influence of various parameters (intrinsic to the amphiphilic JD and extrinsic—from the environment) on the type of vesicle formed will be discussed. In the third part, we will review the numerous biomedical applications of these vesicles of nano- or micron-size. View Full-Text
Keywords: Janus dendrimers; amphiphilic dumbbells; self-assembled structures; vesicles; dendrimersomes; drug delivery systems; theranostics; artificial cells; lectin recognition; self-sorting Janus dendrimers; amphiphilic dumbbells; self-assembled structures; vesicles; dendrimersomes; drug delivery systems; theranostics; artificial cells; lectin recognition; self-sorting
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Taabache, S.; Bertin, A. Vesicles from Amphiphilic Dumbbells and Janus Dendrimers: Bioinspired Self-Assembled Structures for Biomedical Applications. Polymers 2017, 9, 280.

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