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Polymers 2017, 9(6), 214; doi:10.3390/polym9060214

Preparation and Chromatographic Application of β-Cyclodextrin Molecularly Imprinted Microspheres for Paeoniflorin

1
School of Chemical Engineering, University of Science and Technology, Anshan 114051, Liaoning, China
2
Liaoning Provincial Key Laboratory of Fine Separation Technique, University of Science and Technology, Anshan 114051, Liaoning, China
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick van Rijn
Received: 27 April 2017 / Revised: 3 June 2017 / Accepted: 7 June 2017 / Published: 9 June 2017
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Abstract

The application of molecular imprinting technology in the separation and purification of active ingredients in natural products was widely reported, but remains a challenge. Enrichment and separation are especially limited. A surface imprinting technique was reported to synthesize molecularly imprinted microspheres (MIMs) in this article. With paeoniflorin (PF) as the template molecule, β-cyclodextrin (β-CD) and acrylamide (AA) as the functional monomers, and poly(glycidyl methacrylate, GMA) microspheres (PGMA) as the backing material. MIMs have been characterized by FTIR and FESEM. Adsorption experiments indicated the adsorption capacity of MIMs was superior to those comparative non-imprinted microspheres (NIMs) and the binding isotherm of MIMs was in good agreement with the two-site binding model. The baseline separation of PF and its structural analogue albiflorin (AF) were achieved on the new MIMs packed column. MIMs showed good affinity and efficiency for separation of PF and AF compared with those comparative NIMs. The approach of fabricating MIMs is simple, rapid, and inexpensive, and may shed new light on the application of MIMs as a liquid chromatography stationary phase to separate and analyze PF and AF from the Red peony root extracts. View Full-Text
Keywords: molecular imprinting; stationary phase; paeoniflorin; chromatographic application molecular imprinting; stationary phase; paeoniflorin; chromatographic application
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Zhang, W.; Wei, B.; Li, S.; Wang, Y.; Wang, S. Preparation and Chromatographic Application of β-Cyclodextrin Molecularly Imprinted Microspheres for Paeoniflorin. Polymers 2017, 9, 214.

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