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Polymers 2017, 9(6), 213; doi:10.3390/polym9060213

Multifunctional Polymer Nanoparticles for Dual Drug Release and Cancer Cell Targeting

1
Department of Biomedical Engineering, National Yang Ming University, Taipei 11221, Taiwan
2
Department of Pharmacy, China Medical University, Taichung 40402, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editors: Chih-Feng Huang, Jinlian Hu and Rui Xiao
Received: 19 May 2017 / Revised: 6 June 2017 / Accepted: 6 June 2017 / Published: 9 June 2017
(This article belongs to the Special Issue Functionally Responsive Polymeric Materials)
View Full-Text   |   Download PDF [2609 KB, uploaded 9 June 2017]   |  

Abstract

Multifunctional polymer nanoparticles have been developed for cancer treatment because they could be easily designed to target cancer cells and to enhance therapeutic efficacy according to cancer hallmarks. In this study, we synthesized a pH-sensitive polymer, poly(methacrylic acid-co-histidine/doxorubicin/biotin) (HBD) in which doxorubicin (DOX) was conjugated by a hydrazone bond to encapsulate an immunotherapy drug, imiquimod (IMQ), to form dual cancer-targeting and dual drug-loaded nanoparticles. At low pH, polymeric nanoparticles could disrupt and simultaneously release DOX and IMQ. Our experimental results show that the nanoparticles exhibited pH-dependent drug release behavior and had an ability to target cancer cells via biotin and protonated histidine. View Full-Text
Keywords: polymeric nanoparticles; pH-sensitive; multifunctional polymer; imiquimod polymeric nanoparticles; pH-sensitive; multifunctional polymer; imiquimod
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Wen, Y.-H.; Lee, T.-Y.; Fu, P.-C.; Lo, C.-L.; Chiang, Y.-T. Multifunctional Polymer Nanoparticles for Dual Drug Release and Cancer Cell Targeting. Polymers 2017, 9, 213.

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