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Polymers 2017, 9(6), 191; doi:10.3390/polym9060191

In Vitro Biocompatibility, Radiopacity, and Physical Property Tests of Nano-Fe3O4 Incorporated Poly-l-lactide Bone Screws

1
School of Organic and Polymeric, National Taipei University of Technology, Taipei 10608, Taiwan
2
Dental Department, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
3
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan
4
Department of General Dentistry, Chang Gung Memorial Hospital, Taipei 10507, Taiwan
5
Chang Gung University, Taoyuan 33371, Taiwan
6
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan
7
Dental Department, Taipei Medical University Shuang-Ho Hospital, New Taipei City 23561, Taiwan
8
Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei 11031, Taiwan
9
Ph.D Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
Hsin-Ta Wang and Pao-Chang Chiang contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Insung S. Choi and João F. Mano
Received: 18 April 2017 / Revised: 20 May 2017 / Accepted: 24 May 2017 / Published: 26 May 2017
View Full-Text   |   Download PDF [4507 KB, uploaded 28 May 2017]   |  

Abstract

The aim of this study was to fabricate biodegradable poly-l-lactic acid (PLLA) bone screws containing iron oxide (Fe3O4) nanoparticles, which are radiopaque and 3D-printable. The PLLA composites were fabricated by loading 20%, 30%, and 40% Fe3O4 nanoparticles into the PLLA. The physical properties, including elastic modulus, thermal properties, and biocompatibility of the composites were tested. The 20% nano-Fe3O4/PLLA composite was used as the material for fabricating the 3D-printed bone screws. The mechanical performance of the nano-Fe3O4/PLLA bone screws was evaluated by anti-bending and anti-torque strength tests. The tissue response and radiopacity of the nano-Fe3O4/PLLA bone screws were assessed by histologic and CT imaging studies using an animal model. The addition of nano-Fe3O4 increased the crystallization of the PLLA composites. Furthermore, the 20% nano-Fe3O4/PLLA composite exhibited the highest thermal stability compared to the other Fe3O4 proportions. The 3D-printed bone screws using the 20% nano-Fe3O4/PLLA composite provided excellent local tissue response. In addition, the radiopacity of the 20% nano-Fe3O4/PLLA screw was significantly better compared with the neat PLLA screw. View Full-Text
Keywords: radiopaque polymer; 3D printed bone screw; iron oxide nanoparticles; poly-l-lactic acid radiopaque polymer; 3D printed bone screw; iron oxide nanoparticles; poly-l-lactic acid
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MDPI and ACS Style

Wang, H.-T.; Chiang, P.-C.; Tzeng, J.-J.; Wu, T.-L.; Pan, Y.-H.; Chang, W.-J.; Huang, H.-M. In Vitro Biocompatibility, Radiopacity, and Physical Property Tests of Nano-Fe3O4 Incorporated Poly-l-lactide Bone Screws. Polymers 2017, 9, 191.

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