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Erratum published on 14 June 2017, see Polymers 2017, 9(6), 225.

Open AccessReview
Polymers 2017, 9(4), 137; doi:10.3390/polym9040137

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

1
Department of Chemistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
2
Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, 54000 Lahore, Pakistan
3
Centre for Foundation Studies in Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
4
Department of Physics, Faculty of Science Semlalia Marrakesh, Cadi Ayyad University, 40000 Marrakesh, Morocco
*
Author to whom correspondence should be addressed.
Academic Editor: Wei Min Huang
Received: 10 March 2017 / Revised: 6 April 2017 / Accepted: 6 April 2017 / Published: 12 April 2017
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Abstract

Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pKa and pKb values on the ionization, consequent swelling, and targeted drug release are also highlighted. View Full-Text
Keywords: pH sensitive hydrogels; swelling and drug release mechanism; biocompatible materials; drug delivery applications pH sensitive hydrogels; swelling and drug release mechanism; biocompatible materials; drug delivery applications
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rizwan, M.; Yahya, R.; Hassan, A.; Yar, M.; Azzahari, A.D.; Selvanathan, V.; Sonsudin, F.; Abouloula, C.N. pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications. Polymers 2017, 9, 137.

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