Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex
AbstractThe blood-type-mismatch problem, in addition to shortage of blood donation, in blood transfusion has prompted the researchers to develop universal blood that does not require blood typing. In this work, the “cell-in-shell” (i.e., artificial spore) approach is utilized to shield the immune-provoking epitopes on the surface of red blood cells (RBCs). Individual RBCs are successfully coated with supramolecular metal-organic coordination complex of ferric ion (FeIII) and tannic acid (TA). The use of isotonic saline (0.85% NaCl) is found to be critical in the formation of stable, reasonably thick (20 nm) shells on RBCs without any aggregation and hemolysis. The formed “RBC-in-shell” structures maintain their original shapes, and effectively attenuate the antibody-mediated agglutination. Moreover, the oxygen-carrying capability of RBCs is not deteriorated after shell formation. This work suggests a simple but fast method for generating immune-camouflaged RBCs, which would contribute to the development of universal blood. View Full-Text
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Park, T.; Kim, J.Y.; Cho, H.; Moon, H.C.; Kim, B.J.; Park, J.H.; Hong, D.; Park, J.; Choi, I.S. Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex. Polymers 2017, 9, 140.
Park T, Kim JY, Cho H, Moon HC, Kim BJ, Park JH, Hong D, Park J, Choi IS. Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex. Polymers. 2017; 9(4):140.Chicago/Turabian Style
Park, Taegyun; Kim, Ji Yup; Cho, Hyeoncheol; Moon, Hee Chul; Kim, Beom Jin; Park, Ji Hun; Hong, Daewha; Park, Joonhong; Choi, Insung S. 2017. "Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex." Polymers 9, no. 4: 140.
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