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Polymers 2017, 9(3), 82; doi:10.3390/polym9030082

Cell Proliferation on Polyethylene Terephthalate Treated in Plasma Created in SO2/O2 Mixtures

1
Jozef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia
2
Jozef Stefan International Postgraduate School, Jamova cesta 39, 1000 Ljubljana, Slovenia
3
National Institute of Biology, Vecna pot 111, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Academic Editor: Insung S. Choi
Received: 3 January 2017 / Revised: 20 February 2017 / Accepted: 22 February 2017 / Published: 25 February 2017
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Abstract

Samples of polymer polyethylene terephthalate were exposed to a weakly ionized gaseous plasma to modify the polymer surface properties for better cell cultivation. The gases used for treatment were sulfur dioxide and oxygen of various partial pressures. Plasma was created by an electrodeless radio frequency discharge at a total pressure of 60 Pa. X-ray photoelectron spectroscopy showed weak functionalization of the samples’ surfaces with the sulfur, with a concentration around 2.5 at %, whereas the oxygen concentration remained at the level of untreated samples, except when the gas mixture with oxygen concentration above 90% was used. Atomic force microscopy revealed highly altered morphology of plasma-treated samples; however, at high oxygen partial pressures this morphology vanished. The samples were then incubated with human umbilical vein endothelial cells. Biological tests to determine endothelialization and possible toxicity of the plasma-treated polyethylene terephthalate samples were performed. Cell metabolic activity (MTT) and in vitro toxic effects of unknown compounds (TOX) were assayed to determine the biocompatibility of the treated substrates. The biocompatibility demonstrated a well-pronounced maximum versus gas composition which correlated well with development of the surface morphology. View Full-Text
Keywords: polymer; polyethylene terephthalate (PET); SO2 plasma treatment; surface modification; wettability; X-ray photoelectron spectroscopy (XPS); atomic force microscopy (AFM); human umbilical endothelial cell (HUVEC) proliferation; MTT; toxicity; scanning electron microscopy (SEM) polymer; polyethylene terephthalate (PET); SO2 plasma treatment; surface modification; wettability; X-ray photoelectron spectroscopy (XPS); atomic force microscopy (AFM); human umbilical endothelial cell (HUVEC) proliferation; MTT; toxicity; scanning electron microscopy (SEM)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Recek, N.; Resnik, M.; Zaplotnik, R.; Mozetic, M.; Motaln, H.; Lah-Turnsek, T.; Vesel, A. Cell Proliferation on Polyethylene Terephthalate Treated in Plasma Created in SO2/O2 Mixtures. Polymers 2017, 9, 82.

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