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Polymers 2017, 9(12), 643; doi:10.3390/polym9120643

Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration

Gedeon Richter Plc., Formulation R&D, Gyömrői Street 19-21, H-1103 Budapest, Hungary
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budafoki út 8. 3, H-1103 Budapest, Hungary
University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, Hungary
Author to whom correspondence should be addressed.
Received: 18 October 2017 / Revised: 21 November 2017 / Accepted: 22 November 2017 / Published: 25 November 2017
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Furosemide loaded electrospun fibers were prepared for buccal administration, with the aim of improving the oral bioavailability of the poorly soluble and permeable crystalline drug, which can be achieved by the increased solubility and by the circumvention of the intensive first pass metabolism. The water soluble hydroxypropyl cellulose (HPC) was chosen as a mucoadhesive polymer. In order to improve the electrospinnability of HPC, poly (vinylpyrrolidone) (PVP) was used. During the experiments, the total polymer concentration was kept constant at 15% (w/w), and only the ratio of the two polymers (HPC-PVP = 5:5, 6:4, 7:3, 8:2, 9:1) was changed. A combination of rheological measurements with scanning electron microscopic morphological images of electrospun samples was applied for the determination of the optimum composition of the gels for fiber formation. The crystalline–amorphous transition of furosemide was tracked by Fourier transform infrared spectroscopy. A correlation was found between the rheological properties of the polymer solutions and their electrospinnability, and the consequent morphology of the resultant samples. With decreasing HPC ratio of the system, a transition from the spray-dried droplets to the randomly oriented fibrous structures was observed. The results enable the determination of the polymer ratio for the formation of applicable quality of electrospun fibers. View Full-Text
Keywords: furosemide; electrospinning; hydroxypropyl cellulose; poly (vinylpyrrolidone); storage and loss moduli; scanning electron microscopic images furosemide; electrospinning; hydroxypropyl cellulose; poly (vinylpyrrolidone); storage and loss moduli; scanning electron microscopic images

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kovács, A.; Démuth, B.; Meskó, A.; Zelkó, R. Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration. Polymers 2017, 9, 643.

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