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Polymers 2016, 8(9), 321; doi:10.3390/polym8090321

Bactericidal Effect of Lauric Acid-Loaded PCL-PEG-PCL Nano-Sized Micelles on Skin Commensal Propionibacterium acnes

1
International Master Program of Biomedical Material and Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung Li District, Taoyuan City 32023, Taiwan
2
Department of Biomedical Engineering, Chung Yuan Christian University, 200 Chung-Pei Road, Chung Li District, Taoyuan City 32023, Taiwan
3
Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung Li District, Taoyuan City 32023, Taiwan
4
Department of Chemical Engineering, Industrial University of Ho Chi Minh City, 12 Nguyen Van Bao St., Go Vap, Ho Chi Minh City 7000, Vietnam
5
Graduate Institute of Health Industry Technology and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, No. 261, Wenhua 1st Road, Guishan District, Taoyuan City 33303, Taiwan
6
Department of Dermatology, School of Medicine, University of California, San Diego, CA 92121, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 17 February 2016 / Revised: 14 August 2016 / Accepted: 22 August 2016 / Published: 27 August 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
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Abstract

Acne is the over growth of the commensal bacteria Propionibacterium acnes (P. acnes) on human skin. Lauric acid (LA) has been investigated as an effective candidate to suppress the activity of P. acnes. Although LA is nearly insoluble in water, dimethyl sulfoxide (DMSO) has been reported to effectively solubilize LA. However, the toxicity of DMSO can limit the use of LA on the skin. In this study, LA-loaded poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone) micelles (PCL-PEG-PCL) were developed to improve the bactericidal effect of free LA on P. acnes. The block copolymers mPEG-PCL and PCL-PEG-PCL with different molecular weights were synthesized and characterized using 1H Nuclear Magnetic Resonance spectroscopy (1H NMR), Fourier-transform infrared spectroscopy (FT-IR), Gel Permeation Chromatography (GPC), and Differential Scanning Calorimetry (DSC). In the presence of LA, mPEG-PCL diblock copolymers did not self-assemble into nano-sized micelles. On the contrary, the average particle sizes of the PCL-PEG-PCL micelles ranged from 50–198 nm for blank micelles and 27–89 nm for LA-loaded micelles. The drug loading content increased as the molecular weight of PCL-PEG-PCL polymer increased. Additionally, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of free LA were 20 and 80 μg/mL, respectively. The MICs and MBCs of the micelles decreased to 10 and 40 μg/mL, respectively. This study demonstrated that the LA-loaded micelles are a potential treatment for acne. View Full-Text
Keywords: poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone); lauric acid; micelles; Propionibacterium acnes; drug delivery system; nanoparticles poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone); lauric acid; micelles; Propionibacterium acnes; drug delivery system; nanoparticles
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MDPI and ACS Style

Tran, T.-Q.-M.; Hsieh, M.-F.; Chang, K.-L.; Pho, Q.-H.; Nguyen, V.-C.; Cheng, C.-Y.; Huang, C.-M. Bactericidal Effect of Lauric Acid-Loaded PCL-PEG-PCL Nano-Sized Micelles on Skin Commensal Propionibacterium acnes. Polymers 2016, 8, 321.

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