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Polymers 2016, 8(7), 247; doi:10.3390/polym8070247

An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix

1
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USA
2
Department of Industrial and Manufacturing Engineering, North Dakota State University, Fargo, ND 58105, USA
3
Department of Electrical and Computer Engineering, North Dakota State University, Fargo, ND 58105, USA
4
Department of Polymer Science, University of Akron, Akron, OH 44325, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Jianxun Ding, Carsten Werner and Patrick van Rijn
Received: 25 March 2016 / Revised: 19 June 2016 / Accepted: 21 June 2016 / Published: 30 June 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
View Full-Text   |   Download PDF [3392 KB, uploaded 30 June 2016]   |  

Abstract

With the rising tide of antibiotic resistant bacteria, extending the longevity of the current antibiotic arsenal is becoming a necessity. Developing local, controlled release antibiotic strategies, particularly for difficult to penetrate tissues such as bone, may prove to be a better alternative. Previous efforts to develop an osteoconductive local antibiotic release device for bone were created as solid molded composites; however, intimate contact with host bone was found to be critical to support host bone regrowth; thus, an osteocondconductive antibiotic releasing bone void filling putty was developed. Furthermore, a controlled releasing polymer matrix was refined using pendant-functionalized diols to provide tailorable pharmacokinetics. In vitro pharmacokinetic and bioactivity profiles were compared for a putty formulation with an analogous composition as its molded counterpart as well as four new pendant-functionalized polymers. A best-fit analysis of polymer composition in either small cylindrical disks or larger spheres revealed that the new pendant-functionalized polymers appear to release vancomycin via both diffusion and erosion regardless of the geometry of the putty. In silico simulations, a valuable technique for diffusion mediated controlled release models, will be used to confirm and optimize this property. View Full-Text
Keywords: osteomyelitis; controlled drug release; bone void filler; putty; pharmacokinetics; pendant-functionalized diol osteomyelitis; controlled drug release; bone void filler; putty; pharmacokinetics; pendant-functionalized diol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Curley, J.; Hasan, M.R.; Larson, J.; Brooks, B.D.; Liu, Q.; Jain, T.; Joy, A.; Brooks, A.E. An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix. Polymers 2016, 8, 247.

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