An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix
AbstractWith the rising tide of antibiotic resistant bacteria, extending the longevity of the current antibiotic arsenal is becoming a necessity. Developing local, controlled release antibiotic strategies, particularly for difficult to penetrate tissues such as bone, may prove to be a better alternative. Previous efforts to develop an osteoconductive local antibiotic release device for bone were created as solid molded composites; however, intimate contact with host bone was found to be critical to support host bone regrowth; thus, an osteocondconductive antibiotic releasing bone void filling putty was developed. Furthermore, a controlled releasing polymer matrix was refined using pendant-functionalized diols to provide tailorable pharmacokinetics. In vitro pharmacokinetic and bioactivity profiles were compared for a putty formulation with an analogous composition as its molded counterpart as well as four new pendant-functionalized polymers. A best-fit analysis of polymer composition in either small cylindrical disks or larger spheres revealed that the new pendant-functionalized polymers appear to release vancomycin via both diffusion and erosion regardless of the geometry of the putty. In silico simulations, a valuable technique for diffusion mediated controlled release models, will be used to confirm and optimize this property. View Full-Text
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Curley, J.; Hasan, M.R.; Larson, J.; Brooks, B.D.; Liu, Q.; Jain, T.; Joy, A.; Brooks, A.E. An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix. Polymers 2016, 8, 247.
Curley J, Hasan MR, Larson J, Brooks BD, Liu Q, Jain T, Joy A, Brooks AE. An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix. Polymers. 2016; 8(7):247.Chicago/Turabian Style
Curley, John; Hasan, Mohammad R.; Larson, Jacob; Brooks, Benjamin D.; Liu, Qianhui; Jain, Tanmay; Joy, Abraham; Brooks, Amanda E. 2016. "An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix." Polymers 8, no. 7: 247.
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