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Polymers 2016, 8(5), 158; doi:10.3390/polym8050158

Polymeric Biodegradable Stent Insertion in the Esophagus

1
Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, 600 Yi Shan Road, Shanghai 200233, China
2
Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou 215006, China
3
Nanotechnology Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON N2L 3G1, Canada
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Received: 4 March 2016 / Revised: 3 April 2016 / Accepted: 8 April 2016 / Published: 26 April 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
View Full-Text   |   Download PDF [3756 KB, uploaded 26 April 2016]   |  

Abstract

Esophageal stent insertion has been used as a well-accepted and effective alternative to manage and improve the quality of life for patients diagnosed with esophageal diseases and disorders. Current stents are either permanent or temporary and are fabricated from either metal or plastic. The partially covered self-expanding metal stent (SEMS) has a firm anchoring effect and prevent stent migration, however, the hyperplastic tissue reaction cause stent restenosis and make it difficult to remove. A fully covered SEMS and self-expanding plastic stent (SEPS) reduced reactive hyperplasia but has a high migration rate. The main advantage that polymeric biodegradable stents (BDSs) have over metal or plastic stents is that removal is not require and reduce the need for repeated stent insertion. But the slightly lower radial force of BDS may be its main shortcoming and a post-implant problem. Thus, strengthening support of BDS is a content of the research in the future. BDSs are often temporarily effective in esophageal stricture to relieve dysphagia. In the future, it can be expect that biodegradable drug-eluting stents (DES) will be available to treat benign esophageal stricture, perforations or leaks with additional use as palliative modalities for treating malignant esophageal stricture, as the bridge to surgery or to maintain luminal patency during neoadjuvant chemoradiation. View Full-Text
Keywords: biodegradable stents; polymer; dysphagia; esophageal perforation/leak; malignant esophageal stricture; (refractory) benign esophageal stricture biodegradable stents; polymer; dysphagia; esophageal perforation/leak; malignant esophageal stricture; (refractory) benign esophageal stricture
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, K.; Ling, C.; Yuan, T.; Zhu, Y.; Cheng, Y.; Cui, W. Polymeric Biodegradable Stent Insertion in the Esophagus. Polymers 2016, 8, 158.

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