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Polymers 2016, 8(4), 135; doi:10.3390/polym8040135

The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT

College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
Center of Comprehensive Experimental, Hebei University, Baoding 071002, China
Authors to whom correspondence should be addressed.
Academic Editor: Shin-ichi Yusa
Received: 4 March 2016 / Revised: 28 March 2016 / Accepted: 5 April 2016 / Published: 8 April 2016
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Hyperbranched poly(methylene-bis-acrylamide), poly(bis(N,N-propyl acryl amide)) (HPNPAM) and poly(bis(N,N-butyl acryl amide)) were synthesized by reversible addition-fragmentation chain transfer polymerization. HPNPAMs showed lower critical solution temperature (LCST) due to an appropriate ratio between hydrophilic and hydrophobic groups. The effects of reaction conditions on polymerization were investigated in detail. The structure of HPNPAM was characterized by 1H NMR, FT-IR, Muti detector-size exclusion chromatography (MDSEC) and Ultravioletvisble (UV-Vis). The α value reached 0.20 and DB was 90%, indicating HPNPAMs with compact topology structure were successfully prepared. LCSTs were tuned by Mw and the pH value of the solution. The change of molecular size was assayed by dynamic light scattering and scanning electron microscope. These results indicated that the stable uniform nanomicelles were destroyed and macromolecules aggregated together, forming large particles as temperature exceeded LCST. In addition, after the cells were incubated for 24 h, the cell viability reached 80%, which confirmed this new dual responsive HPNPAM had low cytotoxicity. View Full-Text
Keywords: hyperbranched; backbone; thermo-pH response; RAFT; poly(bis(N,N-propyl acrylamide)) hyperbranched; backbone; thermo-pH response; RAFT; poly(bis(N,N-propyl acrylamide))

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Zhou, S.; Zhang, D.; Bai, L.; Zhao, J.; Wu, Y.; Zhao, H.; Ba, X. The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT. Polymers 2016, 8, 135.

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