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Polymers 2016, 8(11), 406; doi:10.3390/polym8110406

Enhanced Transdermal Permeability via Constructing the Porous Structure of Poloxamer-Based Hydrogel

1
Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
2
Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
3
State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Chih-Feng Huang
Received: 30 September 2016 / Revised: 8 November 2016 / Accepted: 15 November 2016 / Published: 21 November 2016
(This article belongs to the Special Issue Functionally Responsive Polymeric Materials)
View Full-Text   |   Download PDF [3779 KB, uploaded 21 November 2016]   |  

Abstract

A major concern for transdermal drug delivery systems is the low bioavailability of targeted drugs primarily caused by the skin’s barrier function. The resistance to the carrier matrix for the diffusion and transport of drugs, however, is routinely ignored. This study reports a promising and attractive approach to reducing the resistance to drug transport in the carrier matrix, to enhance drug permeability and bioavailability via enhanced concentration-gradient of the driving force for transdermal purposes. This approach simply optimizes and reconstructs the porous channel structure of the carrier matrix, namely, poloxamer 407 (P407)-based hydrogel matrix blended with carboxymethyl cellulose sodium (CMCs). Addition of CMCs was found to distinctly improve the porous structure of the P407 matrix. The pore size approximated to normal distribution as CMCs were added and the fraction of pore number was increased by over tenfold. Transdermal studies showed that P407/CMCs saw a significant increase in drug permeability across the skin. This suggests that P407/CMC with improved porous structure exhibits a feasible and promising way for the development of transdermal therapy with high permeability and bioavailability, thereby avoiding or reducing use of any chemical enhancers. View Full-Text
Keywords: enhanced permeability; hydrogel matrix; porous structure; transdermal drug delivery enhanced permeability; hydrogel matrix; porous structure; transdermal drug delivery
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Wang, W.-Y.; Hui, P.C.L.; Wat, E.; Ng, F.S.F.; Kan, C.-W.; Lau, C.B.S.; Leung, P.-C. Enhanced Transdermal Permeability via Constructing the Porous Structure of Poloxamer-Based Hydrogel. Polymers 2016, 8, 406.

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