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Polymers 2013, 5(2), 431-526; doi:10.3390/polym5020431

Synthesis of Glycopolymer Architectures by Reversible-Deactivation Radical Polymerization

1,* and 2,†,*
Ingénierie des Matériaux Polymères, INSA Lyon, Villeurbanne F-69621, France
Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP53, Grenoble cedex 9 38041, France
Affiliated with Université Joseph Fourier, and member of the Institut de Chimie Moléculaire de Grenoble.
Authors to whom correspondence should be addressed.
Received: 22 March 2013 / Revised: 1 May 2013 / Accepted: 3 May 2013 / Published: 21 May 2013
(This article belongs to the Special Issue Bioconjugates/Biohybrid Polymers)


This review summarizes the state of the art in the synthesis of well-defined glycopolymers by Reversible-Deactivation Radical Polymerization (RDRP) from its inception in 1998 until August 2012. Glycopolymers architectures have been successfully synthesized with four major RDRP techniques: Nitroxide-mediated radical polymerization (NMP), cyanoxyl-mediated radical polymerization (CMRP), atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization. Over 140 publications were analyzed and their results summarized according to the technique used and the type of monomer(s) and carbohydrates involved. Particular emphasis was placed on the experimental conditions used, the structure obtained (comonomer distribution, topology), the degree of control achieved and the (potential) applications sought. A list of representative examples for each polymerization process can be found in tables placed at the beginning of each section covering a particular RDRP technique.
Keywords: carbohydrate; glycomonomer; glycopolymer; RDRP; NMP; CMRP; ATRP; RAFT carbohydrate; glycomonomer; glycopolymer; RDRP; NMP; CMRP; ATRP; RAFT

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ghadban, A.; Albertin, L. Synthesis of Glycopolymer Architectures by Reversible-Deactivation Radical Polymerization. Polymers 2013, 5, 431-526.

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