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Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy
Department of Pharmaceutical and Applied Chemistry, University of Siena, Via A. Moro 2, I-53100 Siena, Italy
* Author to whom correspondence should be addressed.
Received: 31 January 2012; in revised form: 15 March 2012 / Accepted: 20 March 2012 / Published: 27 March 2012
Abstract: A series of homopolymeric and copolymeric hydrogels containing the N-isopropylacrylamide and vinyl monomers with α-amino acid (L-valine and L-phenylalanine) residues have been synthesized and their swelling properties were evaluated under different external stimulations. The hydrogels, obtained with different cross-linking agents (EBA and PEG-DA), have shown unique properties such as biocompatibility in addition to the stimuli-responsive characters. These ‘smart’ hydrogels exhibit single or multiple stimuli-responsiveness which could be used in biomedical applications, including controlled drug delivery. This article focuses on recent developments dealing with the delivery of metal-based drug (cisplatin, lithium) from the stimuli-responsive hydrogels proposed as platforms for cancer and bipolar disorder therapies.
Keywords: stimuli-responsive hydrogels; cisplatin chemotherapy; melanoma cells; lithium; bipolar disorder
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Casolaro, M.; Casolaro, I. Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy. Polymers 2012, 4, 964-985.
Casolaro M, Casolaro I. Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy. Polymers. 2012; 4(2):964-985.
Casolaro, Mario; Casolaro, Ilaria. 2012. "Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy." Polymers 4, no. 2: 964-985.