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Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy
AbstractA series of homopolymeric and copolymeric hydrogels containing the N-isopropylacrylamide and vinyl monomers with α-amino acid (L-valine and L-phenylalanine) residues have been synthesized and their swelling properties were evaluated under different external stimulations. The hydrogels, obtained with different cross-linking agents (EBA and PEG-DA), have shown unique properties such as biocompatibility in addition to the stimuli-responsive characters. These ‘smart’ hydrogels exhibit single or multiple stimuli-responsiveness which could be used in biomedical applications, including controlled drug delivery. This article focuses on recent developments dealing with the delivery of metal-based drug (cisplatin, lithium) from the stimuli-responsive hydrogels proposed as platforms for cancer and bipolar disorder therapies.
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Casolaro, M.; Casolaro, I. Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy. Polymers 2012, 4, 964-985.View more citation formats
Casolaro M, Casolaro I. Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy. Polymers. 2012; 4(2):964-985.Chicago/Turabian Style
Casolaro, Mario; Casolaro, Ilaria. 2012. "Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy." Polymers 4, no. 2: 964-985.