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Polymers 2012, 4(2), 964-985; doi:10.3390/polym4020964

Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy

*  and
Department of Pharmaceutical and Applied Chemistry, University of Siena, Via A. Moro 2, I-53100 Siena, Italy
* Author to whom correspondence should be addressed.
Received: 31 January 2012 / Revised: 15 March 2012 / Accepted: 20 March 2012 / Published: 27 March 2012
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A series of homopolymeric and copolymeric hydrogels containing the N-isopropylacrylamide and vinyl monomers with α-amino acid (L-valine and L-phenylalanine) residues have been synthesized and their swelling properties were evaluated under different external stimulations. The hydrogels, obtained with different cross-linking agents (EBA and PEG-DA), have shown unique properties such as biocompatibility in addition to the stimuli-responsive characters. These ‘smart’ hydrogels exhibit single or multiple stimuli-responsiveness which could be used in biomedical applications, including controlled drug delivery. This article focuses on recent developments dealing with the delivery of metal-based drug (cisplatin, lithium) from the stimuli-responsive hydrogels proposed as platforms for cancer and bipolar disorder therapies.
Keywords: stimuli-responsive hydrogels; cisplatin chemotherapy; melanoma cells; lithium; bipolar disorder stimuli-responsive hydrogels; cisplatin chemotherapy; melanoma cells; lithium; bipolar disorder
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Casolaro, M.; Casolaro, I. Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy. Polymers 2012, 4, 964-985.

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