Polymers 2012, 4(2), 986-996; doi:10.3390/polym4020986
Review

The Interactions between Blood and Polymeric Nanoparticles Depend on the Nature and Structure of the Hydrogel Covering the Surface

Received: 28 February 2012; in revised form: 30 March 2012 / Accepted: 1 April 2012 / Published: 13 April 2012
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Abstract: Polymeric surfaces in contact with blood in vivo are foreign bodies and are quickly isolated from blood by the non-specific defense systems. Nanoparticles (NP) used as drug carriers are normally quickly taken up by phagocytes and sequestered in liver and spleen to which they can deliver drugs. Long-circulating and/or low complement activating core-shell NPs can be obtained from PEO/PEG amphiphilic copolymers forming brush or loops on the surface. Core-shell NPs can also be obtained from polysaccharidic graft or block amphiphilic copolymers. Complement activation by the NPs and protein adsorption both depend on the structure, nature and molecular weight of the polysaccharide chains composing the shell. NPs showing low complement activation can be obtained if the polysaccharide on the surface is long and in a brush configuration. Fragile molecules such as hemoglobin or siRNA can be loaded and protected by appropriate brush shells without modifying the low complement activation properties.
Keywords: core-shell nanoparticles; amphiphilic copolymers; PEO/PEG; polysaccharides; surface properties; complement activation; blood plasma proteins adsorption; long circulation
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MDPI and ACS Style

Labarre, D. The Interactions between Blood and Polymeric Nanoparticles Depend on the Nature and Structure of the Hydrogel Covering the Surface. Polymers 2012, 4, 986-996.

AMA Style

Labarre D. The Interactions between Blood and Polymeric Nanoparticles Depend on the Nature and Structure of the Hydrogel Covering the Surface. Polymers. 2012; 4(2):986-996.

Chicago/Turabian Style

Labarre, Denis. 2012. "The Interactions between Blood and Polymeric Nanoparticles Depend on the Nature and Structure of the Hydrogel Covering the Surface." Polymers 4, no. 2: 986-996.


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