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Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide
V.A. Fock Institute of Physics, Saint Petersburg State University, Ulianovskaja st. 1, 198504 Saint Petersburg, Russia
Institute of Macromolecular Compounds RAS, Bolshoi pr. 31, 199004 Saint Petersburg, Russia
Institut des Biomolécules Max Mousseron (IBMM, UMR 5247 CNRS-Université de Montpellier1- Université de Montpellier 2), Place Eugène Bataillon, CC 1706, 34095 Montpellier Cedex 5, France
* Author to whom correspondence should be addressed.
Received: 2 November 2011; in revised form: 20 December 2011 / Accepted: 23 December 2011 / Published: 2 January 2012
Abstract: The four first generations of dendrigraft poly-L-lysine have been studied in dimethylformamide (aprotic solvent) and in 0.2 M NaCl aqueous solutions by isothermal translation diffusion, 1H NMR and viscometry methods. The relationships between diffusion coefficient, intrinsic viscosity and molar mass have been determined for dendrigraft poly-L-lysines, and the scaling index values have been compared to classical trifunctional dendrimers. Dendrimers and dendrigraft poly-L-lysines exhibited similitudes in their hydrodynamic behaviors. Nevertheless, dendrigraft poly-L-lysines displayed a specific behavior in solution. In contrast to dendrimers, a significant change of hydrodynamic dimension of dendrigraft poly-L-lysines according to the nature of the solvent has been observed. In aprotic solvent, the dendrigraft poly-L-lysine dimensions are about two times lower than in aqueous media (i.e., the hydrodynamic volume is contracted by a factor 8 in dimethylformamide), revealing the softness of dendrigraft poly-L-lysine compared to classical trifunctional dendrimers.
Keywords: dendrimer; dendrigraft polylysine; hydrodynamic properties; hydrodynamic radii; diffusion coefficient
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Yevlampieva, N.; Dobrodumov, A.; Nazarova, O.; Okatova, O.; Cottet, H. Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide. Polymers 2012, 4, 20-31.
Yevlampieva N, Dobrodumov A, Nazarova O, Okatova O, Cottet H. Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide. Polymers. 2012; 4(1):20-31.
Yevlampieva, Natalia; Dobrodumov, Anatolii; Nazarova, Olga; Okatova, Olga; Cottet, Hervé. 2012. "Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide." Polymers 4, no. 1: 20-31.