Abstract: The four first generations of dendrigraft poly-L-lysine have been studied in dimethylformamide (aprotic solvent) and in 0.2 M NaCl aqueous solutions by isothermal translation diffusion, 1H NMR and viscometry methods. The relationships between diffusion coefficient, intrinsic viscosity and molar mass have been determined for dendrigraft poly-L-lysines, and the scaling index values have been compared to classical trifunctional dendrimers. Dendrimers and dendrigraft poly-L-lysines exhibited similitudes in their hydrodynamic behaviors. Nevertheless, dendrigraft poly-L-lysines displayed a specific behavior in solution. In contrast to dendrimers, a significant change of hydrodynamic dimension of dendrigraft poly-L-lysines according to the nature of the solvent has been observed. In aprotic solvent, the dendrigraft poly-L-lysine dimensions are about two times lower than in aqueous media (i.e., the hydrodynamic volume is contracted by a factor 8 in dimethylformamide), revealing the softness of dendrigraft poly-L-lysine compared to classical trifunctional dendrimers.
Keywords: dendrimer; dendrigraft polylysine; hydrodynamic properties; hydrodynamic radii; diffusion coefficient
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Yevlampieva, N.; Dobrodumov, A.; Nazarova, O.; Okatova, O.; Cottet, H. Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide. Polymers 2012, 4, 20-31.
Yevlampieva N, Dobrodumov A, Nazarova O, Okatova O, Cottet H. Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide. Polymers. 2012; 4(1):20-31.
Yevlampieva, Natalia; Dobrodumov, Anatolii; Nazarova, Olga; Okatova, Olga; Cottet, Hervé. 2012. "Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide." Polymers 4, no. 1: 20-31.