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Polymers 2012, 4(1), 20-31; doi:10.3390/polym4010020

Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide

1 V.A. Fock Institute of Physics, Saint Petersburg State University, Ulianovskaja st. 1, 198504 Saint Petersburg, Russia 2 Institute of Macromolecular Compounds RAS, Bolshoi pr. 31, 199004 Saint Petersburg, Russia 3 Institut des Biomolécules Max Mousseron (IBMM, UMR 5247 CNRS-Université de Montpellier1- Université de Montpellier 2), Place Eugène Bataillon, CC 1706, 34095 Montpellier Cedex 5, France
* Author to whom correspondence should be addressed.
Received: 2 November 2011 / Revised: 20 December 2011 / Accepted: 23 December 2011 / Published: 2 January 2012
(This article belongs to the Special Issue Dendrimers and Hyperbranched Polymers)
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The four first generations of dendrigraft poly-L-lysine have been studied in dimethylformamide (aprotic solvent) and in 0.2 M NaCl aqueous solutions by isothermal translation diffusion, 1H NMR and viscometry methods. The relationships between diffusion coefficient, intrinsic viscosity and molar mass have been determined for dendrigraft poly-L-lysines, and the scaling index values have been compared to classical trifunctional dendrimers. Dendrimers and dendrigraft poly-L-lysines exhibited similitudes in their hydrodynamic behaviors. Nevertheless, dendrigraft poly-L-lysines displayed a specific behavior in solution. In contrast to dendrimers, a significant change of hydrodynamic dimension of dendrigraft poly-L-lysines according to the nature of the solvent has been observed. In aprotic solvent, the dendrigraft poly-L-lysine dimensions are about two times lower than in aqueous media (i.e., the hydrodynamic volume is contracted by a factor 8 in dimethylformamide), revealing the softness of dendrigraft poly-L-lysine compared to classical trifunctional dendrimers.
Keywords: dendrimer; dendrigraft polylysine; hydrodynamic properties; hydrodynamic radii; diffusion coefficient dendrimer; dendrigraft polylysine; hydrodynamic properties; hydrodynamic radii; diffusion coefficient
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yevlampieva, N.; Dobrodumov, A.; Nazarova, O.; Okatova, O.; Cottet, H. Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide. Polymers 2012, 4, 20-31.

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