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Polymers 2011, 3(3), 1377-1397; doi:10.3390/polym3031377

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

1
Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
2
Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Received: 20 June 2011 / Revised: 8 August 2011 / Accepted: 22 August 2011 / Published: 26 August 2011
(This article belongs to the Special Issue Bioinspired Polymers)
View Full-Text   |   Download PDF [312 KB, uploaded 26 August 2011]   |  

Abstract

In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer. In particular, PLGA has been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research. This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release. View Full-Text
Keywords: poly lactic-co-glycolic acid; drug delivery; PLGA degradation; sustained release; PLGA fabrication techniques poly lactic-co-glycolic acid; drug delivery; PLGA degradation; sustained release; PLGA fabrication techniques
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Makadia, H.K.; Siegel, S.J. Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Polymers 2011, 3, 1377-1397.

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