Polymers 2011, 3(3), 1243-1254; doi:10.3390/polym3031243
Article

Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli

1email, 2email, 3email, 2email, 2email, 4email, 1email, 1email and 4,* email
Received: 7 June 2011; in revised form: 20 July 2011 / Accepted: 29 July 2011 / Published: 8 August 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Quantum Dots (QDs) have become an interesting subject of study for labeling and drug delivery in biomedical research due to their unique responses to external stimuli. In this paper, the biological effects of a novel hydrogel based QD nano-structure on E. coli bacteria are presented. The experimental evidence reveals that cadmium telluride (CdTe) QDs that are encapsulated inside biocompatible polymeric shells have reduced or negligible toxicity to this model cell system, even when exposed at higher dosages. Furthermore, a preliminary gene expression study indicates that QD-hydrogel nanospheres do not inhibit the Green Fluorescent Protein (GFP) gene expression. As the biocompatible and externally tunable polymer shells possess the capability to control the QD packing density at nanometer scales, the resulting luminescence efficiency of the nanostructures, besides reducing the cytotoxic potential, may be suitable for various biomedical applications.
Keywords: quantum dots; cytotoxicity; hydrogel; drug delivery, temperature responsive
PDF Full-text Download PDF Full-Text [559 KB, uploaded 8 August 2011 11:43 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

GhoshMitra, S.; Cai, T.; Diercks, D.; Hu, Z.; Roberts, J.; Dahiya, J.; Mills, N.; Hynds, D.; Ghosh, S. Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli. Polymers 2011, 3, 1243-1254.

AMA Style

GhoshMitra S, Cai T, Diercks D, Hu Z, Roberts J, Dahiya J, Mills N, Hynds D, Ghosh S. Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli. Polymers. 2011; 3(3):1243-1254.

Chicago/Turabian Style

GhoshMitra, Somesree; Cai, Tong; Diercks, David; Hu, Zhibing; Roberts, James; Dahiya, Jai; Mills, Nathaniel; Hynds, DiAnna; Ghosh, Santaneel. 2011. "Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli." Polymers 3, no. 3: 1243-1254.


Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert