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Polymers 2011, 3(3), 1181-1198; doi:10.3390/polym3031181
Article

Microspheres Containing Cibacron Blue F3G-A and Incorporated Iron Oxide Nanoparticles as Biomarker Harvesting Platforms

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Received: 8 June 2011; in revised form: 11 July 2011 / Accepted: 27 July 2011 / Published: 28 July 2011
(This article belongs to the Special Issue Polymer Nanogels and Microgels)
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Abstract: In this work, magnetic functionality was introduced to cross-linked acrylamide-based particles via the in situ coprecipitation of iron oxide nanoparticles within the hydrogel particle interior. Cibacron Blue F3G-A was then incorporated onto the magnetic hydrogel scaffold to facilitate the harvest of targeted protein species. The dye-loaded magnetic particles were physically characterized, and their protein sequestration performance was investigated. The results of these studies indicated that dye-loaded magnetic particles sequestered a greater amount of lower molecular weight proteins from the test solution than was achieved using reference particles, dye-loaded cross-linked N-isopropylacrylamide-based core-shell particles. This difference in protein harvesting ability may reflect the higher degree of dye-loading in the magnetic particles relative to the dye-loaded core-shell particles.
Keywords: hydrogels; Cibacron Blue F3G-A; iron oxide nanoparticles; affinity dyes hydrogels; Cibacron Blue F3G-A; iron oxide nanoparticles; affinity dyes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Patanarut, A.; Williams, E.H.; Petricoin, E.; Liotta, L.A.; Bishop, B. Microspheres Containing Cibacron Blue F3G-A and Incorporated Iron Oxide Nanoparticles as Biomarker Harvesting Platforms. Polymers 2011, 3, 1181-1198.

AMA Style

Patanarut A, Williams EH, Petricoin E, Liotta LA, Bishop B. Microspheres Containing Cibacron Blue F3G-A and Incorporated Iron Oxide Nanoparticles as Biomarker Harvesting Platforms. Polymers. 2011; 3(3):1181-1198.

Chicago/Turabian Style

Patanarut, Alexis; Williams, Elissa H.; Petricoin, Emanuel; Liotta, Lance A.; Bishop, Barney. 2011. "Microspheres Containing Cibacron Blue F3G-A and Incorporated Iron Oxide Nanoparticles as Biomarker Harvesting Platforms." Polymers 3, no. 3: 1181-1198.


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