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A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings
Department of Bioengineering & Regenerative Medicine, Utah-Inha DDS & Advanced Therapeutics Research Center, B-404 Meet-You-All Tower, Songdo TechnoPark 7-50, Songdo-Dong, Yeonsu-Gu, Incheon, 406-840, Korea
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA
* Author to whom correspondence should be addressed.
Received: 30 May 2011; in revised form: 3 June 2011 / Accepted: 13 June 2011 / Published: 14 June 2011
Abstract: Soft nanogels are submicron-sized hydrophilic structures engineered from biocompatible polymers possessing the characteristics of nanoparticles as well as hydrogels, with a wide array of potential applications in biotechnology and biomedicine, namely, drug and protein delivery. In this work, nanogels were obtained using the physical self-assembly technique or ‘layer-by-layer’ which is based on electrostatic interactions. Liposomal vesicles were coated with alternating layers of hyaluronic acid and chitosan yielding a more viscous hydrogel formulation that previously reported core-shell nanoparticulate suspension, via simply modifying the physico-chemical characteristics of the system. Structural features, size, surface charge, stability and swelling characteristics of the nanogel were studied using scanning electron microscopy and dynamic light scattering. With a specific cranio-maxillofacial application in mind, the hydrogel was loaded with recombinant human (rh) bone morphogenetic protein-7, also known as osteogenic protein-1 or rhOP-1 and release was monitored over an extended period of 60 days. This preliminary study reports promising results on the formulation of a novel core-shell polymeric nanogel.
Keywords: tissue engineering; drug delivery; dentistry; core-shell; liposomes; polymer; biomedicine; nanoncology; bone regeneration; nanoshell; amphiphilic copolymers; nanogel
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Joo, V.; Ramasamy, T.; Haidar, Z.S. A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings. Polymers 2011, 3, 967-974.
Joo V, Ramasamy T, Haidar ZS. A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings. Polymers. 2011; 3(2):967-974.
Joo, Victor; Ramasamy, Thiruganesh; Haidar, Ziyad S. 2011. "A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings." Polymers 3, no. 2: 967-974.