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Polymers 2011, 3(2), 967-974; doi:10.3390/polym3020967
Communication

A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings

1
,
1
 and
1,2,*
1 Department of Bioengineering & Regenerative Medicine, Utah-Inha DDS & Advanced Therapeutics Research Center, B-404 Meet-You-All Tower, Songdo TechnoPark 7-50, Songdo-Dong, Yeonsu-Gu, Incheon, 406-840, Korea 2 Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA
* Author to whom correspondence should be addressed.
Received: 30 May 2011 / Revised: 3 June 2011 / Accepted: 13 June 2011 / Published: 14 June 2011
(This article belongs to the Special Issue Polymers for Oro-Dental and Cranio- Maxillo-Facial Applications)
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Abstract

Soft nanogels are submicron-sized hydrophilic structures engineered from biocompatible polymers possessing the characteristics of nanoparticles as well as hydrogels, with a wide array of potential applications in biotechnology and biomedicine, namely, drug and protein delivery. In this work, nanogels were obtained using the physical self-assembly technique or ‘layer-by-layer’ which is based on electrostatic interactions. Liposomal vesicles were coated with alternating layers of hyaluronic acid and chitosan yielding a more viscous hydrogel formulation that previously reported core-shell nanoparticulate suspension, via simply modifying the physico-chemical characteristics of the system. Structural features, size, surface charge, stability and swelling characteristics of the nanogel were studied using scanning electron microscopy and dynamic light scattering. With a specific cranio-maxillofacial application in mind, the hydrogel was loaded with recombinant human (rh) bone morphogenetic protein-7, also known as osteogenic protein-1 or rhOP-1 and release was monitored over an extended period of 60 days. This preliminary study reports promising results on the formulation of a novel core-shell polymeric nanogel.
Keywords: tissue engineering; drug delivery; dentistry; core-shell; liposomes; polymer; biomedicine; nanoncology; bone regeneration; nanoshell; amphiphilic copolymers; nanogel tissue engineering; drug delivery; dentistry; core-shell; liposomes; polymer; biomedicine; nanoncology; bone regeneration; nanoshell; amphiphilic copolymers; nanogel
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Joo, V.; Ramasamy, T.; Haidar, Z.S. A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings. Polymers 2011, 3, 967-974.

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