Polymers 2011, 3(2), 967-974; doi:10.3390/polym3020967
Communication

A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings

Received: 30 May 2011; in revised form: 3 June 2011 / Accepted: 13 June 2011 / Published: 14 June 2011
(This article belongs to the Special Issue Polymers for Oro-Dental and Cranio- Maxillo-Facial Applications)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Soft nanogels are submicron-sized hydrophilic structures engineered from biocompatible polymers possessing the characteristics of nanoparticles as well as hydrogels, with a wide array of potential applications in biotechnology and biomedicine, namely, drug and protein delivery. In this work, nanogels were obtained using the physical self-assembly technique or ‘layer-by-layer’ which is based on electrostatic interactions. Liposomal vesicles were coated with alternating layers of hyaluronic acid and chitosan yielding a more viscous hydrogel formulation that previously reported core-shell nanoparticulate suspension, via simply modifying the physico-chemical characteristics of the system. Structural features, size, surface charge, stability and swelling characteristics of the nanogel were studied using scanning electron microscopy and dynamic light scattering. With a specific cranio-maxillofacial application in mind, the hydrogel was loaded with recombinant human (rh) bone morphogenetic protein-7, also known as osteogenic protein-1 or rhOP-1 and release was monitored over an extended period of 60 days. This preliminary study reports promising results on the formulation of a novel core-shell polymeric nanogel.
Keywords: tissue engineering; drug delivery; dentistry; core-shell; liposomes; polymer; biomedicine; nanoncology; bone regeneration; nanoshell; amphiphilic copolymers; nanogel
PDF Full-text Download PDF Full-Text [432 KB, uploaded 14 June 2011 15:20 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Joo, V.; Ramasamy, T.; Haidar, Z.S. A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings. Polymers 2011, 3, 967-974.

AMA Style

Joo V, Ramasamy T, Haidar ZS. A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings. Polymers. 2011; 3(2):967-974.

Chicago/Turabian Style

Joo, Victor; Ramasamy, Thiruganesh; Haidar, Ziyad S. 2011. "A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings." Polymers 3, no. 2: 967-974.

Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert